Lab Altman
Widespread Expression of PICOT in Mouse and Human Tissues With Predominant Localization to Epithelium
Protein kinase C Θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria
Antigen-independent signalosome of CARMA1, PKC(theta), and TNF receptor-associated factor 2 (TRAF2) determines NF-{kappa}B signaling in T cells
Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy
To kill, you have to duck an HDAC
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
Itk controls the spatiotemporal organization of T cell activation
PKCQ: a new target for selective immunosuppression
SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU)
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors
Protein kinace CΘ C2 domainis a phosphotyrosine binding module that plays a key role in its activation
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner
In and out of the bull’s eye: protein kinase Cs in the immunological synapse
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter
Regulation of immune system cell functions by protein kinase C
The yin and yang of protein kinase C-theya (PKCΘ): a novel drug target for selective immunosuppression
Protein C-η controls CTLA-4-mediated regulatory T cell function
Association of the EF-hand and PH domains of the guanine nucleotide exchange factor PLAT with IP3 receptor 1 promotes Ca2+ signaling in T cells
Protein kinase C inhibitors for immune disorders
TCR-induced sumoylation of the kinase PKC-Θ controls T cell synapse organization and T cell activation
SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1
Protein kinase C enzymes in the hematopoietic and immune systems
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
Chemical proteomic map of dimethyl fumarate-sensitive cyteines in primary human T cells
Identification of a novel alternatively spliced form of inflammatory regulator SWAP-70-like adapter of T cells
NFKB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality
Phosphoproteomics reveals regulatory T cell-mediated DEF6 dephosphorylation that affects cytokine expression in human conventional T cells
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity
Role of TRAFs in signaling pathways controlling T follicular helper cell differentiation and T cell-dependent antibody responses
PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene
Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity
Protein Kinase C-η Deficiency Does Not Impair Antiviral Immunity and CD8+ T Cell Activation
PKCq
PKC enzymes play critical roles in the differentiation and proliferation of many cell types, including T cells, and in the response to diverse stimuli. Little is known, however, about the substrate specificity and role of individual PKC isoforms in distinct…
SLAT, a T Cell-Specific Signaling Protein
In 2003, we reported the isolation and initial characterization of a novel signaling protein, termed SWAP-70-Like Adaptor of T cells (SLAT; aka Def6), which is selectively expressed in T cells. Upon antigen stimulation, SLAT selectively localizes to the T cell…
A Novel CTLA4-Mediated Treg Cell-Intrinsic Signaling Pathway
Recent work by others has provided evidence that, in contrast to conventional T cells, PKCq negatively regulates the suppressive activity of Treg cells. Therefore, we initiated efforts to identify other member(s) of the PKC enzyme family, which might positively regulate…
