Lab Altman
Protein kinase C Θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria
Widespread Expression of PICOT in Mouse and Human Tissues With Predominant Localization to Epithelium
Antigen-independent signalosome of CARMA1, PKC(theta), and TNF receptor-associated factor 2 (TRAF2) determines NF-{kappa}B signaling in T cells
Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy
To kill, you have to duck an HDAC
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
Itk controls the spatiotemporal organization of T cell activation
PKCQ: a new target for selective immunosuppression
SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU)
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors
Protein kinace CΘ C2 domainis a phosphotyrosine binding module that plays a key role in its activation
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner
In and out of the bull’s eye: protein kinase Cs in the immunological synapse
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter
Regulation of immune system cell functions by protein kinase C
The yin and yang of protein kinase C-theya (PKCΘ): a novel drug target for selective immunosuppression
Protein C-η controls CTLA-4-mediated regulatory T cell function
Association of the EF-hand and PH domains of the guanine nucleotide exchange factor PLAT with IP3 receptor 1 promotes Ca2+ signaling in T cells
Protein kinase C inhibitors for immune disorders
TCR-induced sumoylation of the kinase PKC-Θ controls T cell synapse organization and T cell activation
SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1
Protein kinase C enzymes in the hematopoietic and immune systems
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
Chemical proteomic map of dimethyl fumarate-sensitive cyteines in primary human T cells
Identification of a novel alternatively spliced form of inflammatory regulator SWAP-70-like adapter of T cells
NFKB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality
Phosphoproteomics reveals regulatory T cell-mediated DEF6 dephosphorylation that affects cytokine expression in human conventional T cells
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity
Role of TRAFs in signaling pathways controlling T follicular helper cell differentiation and T cell-dependent antibody responses
PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene
Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity
Protein Kinase C-η Deficiency Does Not Impair Antiviral Immunity and CD8+ T Cell Activation
SLAT, a T Cell-Specific Signaling Protein
In 2003, we reported the isolation and initial characterization of a novel signaling protein, termed SWAP-70-Like Adaptor of T cells (SLAT; aka Def6), which is selectively expressed in T cells. Upon antigen stimulation, SLAT selectively localizes to the T cell…
A Novel CTLA4-Mediated Treg Cell-Intrinsic Signaling Pathway
Recent work by others has provided evidence that, in contrast to conventional T cells, PKCq negatively regulates the suppressive activity of Treg cells. Therefore, we initiated efforts to identify other member(s) of the PKC enzyme family, which might positively regulate…
PKCq
PKC enzymes play critical roles in the differentiation and proliferation of many cell types, including T cells, and in the response to diverse stimuli. Little is known, however, about the substrate specificity and role of individual PKC isoforms in distinct…
