Lab Benedict
Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything
Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-kB p50
Sources and signals regulating type I interferon production: lessons learned from cytomegalovirus
B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence
The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responsesc
Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations
Dissecting the requirements for maintenance of the CMV-specific memory T-cell pool
TRAIL: not just for tumors anymore?
Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses
Clinical targeting of the TNF and TNFR superfamilies
Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus
CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection
The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner
SD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cotylytic function by NK cells
A CMV vaccine: TREATing despite the TRICKs
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV
Distinct requirements of activation of NKT and NK cells during viral infection
Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense
Cardif (MAVS) regulates the maturation of NK cells
Cytomeglaovirus-specific CD4 T cells are cytolytic and mediate vaccine protection
cGAS-STING signaling regulates initial innate control of cytomegalovirus infection
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
CMV immune evasion and manipulation of the immune system with aging
Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling
A noncanonical function of cGAMP in inflammasome priming and activation
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8(+) T cells
IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence
Cytomegalovirus: shape-shifting the immune system
Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection
Restriction of human cytomegalovirus infection by galectin-9
Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses
Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell lymphocyte attenuator
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100-Reactive CD4 + T-Regulatory Cells
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4(+) T-Regulatory Cells
Profiling human cytomegalovirus-specific T cell responses reveals novel immunogenic open reading frames
Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation
Divergent metabolic programmes control two populations of mait cells that protect the lung
How ‘late-rising’ T cells combat a stubborn virus
LJI researchers uncover special T cell subset that helps fight cytomegalovirus infection
The immune cell with two faces
"These cells might make a big difference in fighting off viruses"
CMV Interfaces with The Trail Cytokine System
We have recently discovered a novel connection between the TNF-related apoptosis inducing ligand (TRAIL) cytokine system and CMV. TRAIL is a TNF-family cytokine that can bind to several receptors (TRAIL receptor- 1, 2 ,3 and 4), of which two (R1…
T Cell Immunity and CMV
HCMV-specific CD8 T cells protect bone marrow transplant patients when used in cellular immunotherapy, and their long-term maintenance is enhanced by CD4 T cells. Importantly, a robust HCMV-specific CD4 T cell response strongly correlates with protection against congenital infection and…
CMV Targets the Immune Checkpoint Inhibitor BTLA
Virulent isolates of CMV encode the ul144 orf, and we identified UL144 as an orthologue of the herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily. When the immune checkpoint inhibitor B and T lymphocyte attenuator (BTLA) was…
The Lymphotoxin-Interferon Antiviral Immunity Axis
Over the last 15 years our lab has been studying the link between lymphotoxins (LT) and the regulation of type I interferons (IFN-I) during CMV infection. Mice deficient in LT signaling pathways show increased susceptibility to infection with MCMV due…
