Remi Marrocco

We have recently discovered a novel connection between the TNF-related apoptosis inducing ligand (TRAIL) cytokine system and CMV. TRAIL is a TNF-family cytokine that can bind to several receptors (TRAIL receptor- 1, 2 ,3 and 4), of which two (R1…
HCMV-specific CD8 T cells protect bone marrow transplant patients when used in cellular immunotherapy, and their long-term maintenance is enhanced by CD4 T cells. Importantly, a robust HCMV-specific CD4 T cell response strongly correlates with protection against congenital infection and…
Virulent isolates of CMV encode the ul144 orf, and we identified UL144 as an orthologue of the herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily. When the immune checkpoint inhibitor B and T lymphocyte attenuator (BTLA) was…
Over the last 15 years our lab has been studying the link between lymphotoxins (LT) and the regulation of type I interferons (IFN-I) during CMV infection. Mice deficient in LT signaling pathways show increased susceptibility to infection with MCMV due…