How do herpesviruses evade the immune system?
LJI scientists look for new ways to fight a sly family of viruses
Lab Cheroutre
Intraepithelial lymphocytes: unusual T cells at epithelial surfaces. In: Smith PD, MacDonald TT, Blumberg RS, editors.
The many face-lifts of CD4 T helper cells
The 2010 Midwinter Conference of Immunologists at Asilomar
Mucosal T cells in gut homeostasis and inflammation
Regulatory T-cell stability and plasticity in mucosal and systemic immune systems
Hepatic stellate cells function as regulatory bystanders
The light and dark sides of intestinal intraepithelial lymphocytes
Mucosal memory CD8(+) T cells are selected in the periphery by an MHC class I molecure
Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation
Protein kinase C η is required for T cell activation and homeostatic proliferation
Following the fate of one insulin-reactive CD4 T cell: conversion into teffs and tregs in the periphery controls deiabetes in NOD mice
Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase
Got IELs?
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders
A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response
BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection
CD8αα expression marks terminally differentiated homan CD8+ T cells expanded in chronic viral infection
Themis sets the signal threshold for positive and negative selection in T-cell development
CD4 CTL: living up to the challenge
αβT cell receptors expressed by CD4(-)CD8αβ(-) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities
Negative selection of self-reactive chicken B cells requires B cell receptor signaling and is independent of bursal microenvironment
Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells
IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis
T-cell expression o fIL-10 is essential for tumor immune surveillance in the small intestine
Critical role of fibroblast-like synoviocytes glycolytic metabolizm in rheumatoid arthritis
Retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system
Critical role of glucose metabolism in rheumatoid arthritis fibroblast-like synoviocytes
Transcriptomes and metabolism define mouse and human mait cell populations
Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner
LIGHT-HVEM signaling in innate lymphoid cell subsets protects against enteric bacterial infection
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection.
A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor alpha determines t cell activation and function
Hilde Cheroutre named AAI Distinguished Fellow
Leading immunologist honored for research into the roots of autoimmunity, cancer development, and more
New LJI research has major implications for controlling T cell activity
How a supposed "nuclear" receptor makes TCR signaling possible
Origin story: How T cell heroes and villains are made
LJI Postdoctoral Fellow Greet Verstichel on how T cells learn their "fate"
Mucosal CD4- CD8- T Cells
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium of the small intestine in humans and mice. intraepithelial T cells are distinct from conventional T cells with regard to…
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4 T cells and directed towards dietary gluten. CD is the prototype of diseases in which a clear role of antigen-specific…
Regulation of mucosal immunity by stromal cells and dendritic cells crosstalk in the gut
Genetic regulation by vitamin A is involved in multiple biological processes such as embryonic development, vision, and immunity. To exert this regulatory role, vitamin A is oxidized into its active form by retinol dehydrogenases followed by retinal dehydrogenases (RALDH). The…
T Cells
One large subgroup of these specialized T cells is encompassed by the IEL which are located in the epithelium of the small intestine in humans and mice. IEL are distinct from conventional T cells with regard to phenotype and function,…
T Cell Function
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role in controlling autoimmune diseases, graft rejections and tumor rejection. We are also investigating the critical role of the DCs in…
CD4+ Cytotoxic Lymphocytes
MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system can take to prepare the host to deal with challenges including infections, cancers and autoimmunity. CD4+ T cells that initially…
Mechanisms Involved in The Generation of High Affinity Effector Memory T Cells
A hallmark of immune memory is that repeated infections are met with accelerated or/and enhanced protective immunity. Furthermore, unlike naive T lymphocytes or central memory T cells, which reside in lymphoid tissues, some antigen-experienced T cells gain the ability to…
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance for T cells is initially established during thymic selection and based on the affinity/avidity of the αβTCR for self-antigen/Major Histocompatibility…
