Lab Crotty

Crotty

Shane Crotty

Crotty looks at camera and smiles. He is wearing a blue button-down

Ricardo Monterrosa
October 28, 2024

Crotty

Sydney Ramirez

Ricardo Monterrosa
October 28, 2024

Crotty

Tasha Altheide

Ricardo Monterrosa
October 28, 2024

Crotty

Sonya Haupt

Ricardo Monterrosa
October 28, 2024

Crotty

Monica Rodriguez Farias

mtalbott
October 28, 2024

Crotty

Monolina Shil

Ricardo Monterrosa
October 28, 2024

Crotty

Natalie Hern

mtalbott
October 28, 2024

Crotty

Osirus Eisenman

mtalbott
October 28, 2024

Crotty

Pablo Lucas Ezequiel Garin Ortega

Ricardo Monterrosa
October 28, 2024

Crotty

Parham Ramezani-Rad

Ricardo Monterrosa
October 28, 2024

Crotty

Patrick Madden

mtalbott
October 28, 2024

Crotty

Paul Gabriel Lopez

Ricardo Monterrosa
October 28, 2024

Crotty

Leonard Hills

mtalbott
October 28, 2024

Crotty

Martin Schuetz

mtalbott
October 28, 2024

Crotty

Jennifer Dan

Ricardo Monterrosa
October 28, 2024

Crotty

Kristina Edwards

mtalbott
October 28, 2024

Crotty

Farhoud Faraji

Photo portrait of Farhoud Faraji

Ricardo Monterrosa
October 28, 2024

Crotty

Hannah Stacey

Ricardo Monterrosa
October 28, 2024

Crotty

Henry Sutton

mtalbott
October 28, 2024

Crotty

Ivy Phung

Ricardo Monterrosa
October 28, 2024

Crotty

Carolyn Moderbacher

Ricardo Monterrosa
October 28, 2024

Crotty

Christina Kim

Ricardo Monterrosa
October 28, 2024

Crotty

Corina Vester

mtalbott
October 28, 2024

Crotty

Da Sol Kuen

Ricardo Monterrosa
October 28, 2024

Crotty

Ester Marina Zarate

Ricardo Monterrosa
October 28, 2024

Crotty

Amber Myers

Ricardo Monterrosa
October 28, 2024

Crotty

Angel Sarabia

mtalbott
October 28, 2024

Crotty

Brian Freeman

Ricardo Monterrosa
October 28, 2024

In the News

Shane Crotty: A Landmark Study on Upper Airway Mucosal Immunity

Optimism for Nasal Vaccines for Covid and Other Respiratory Pathogens

None None
July 31, 2024

Research News

LJI scientists capture immune cells hidden in nasal passages

Portrait photo of Shane Crotty, Ph.D. He is sitting and smiling at the camera

LJI scientists pioneer new method for measuring immune memory and SARS-CoV-2 responses in the upper airway

Madeline McCurry-Schmidt
July 31, 2024

Crotty

Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model

Ricardo Monterrosa
June 6, 2024

Crotty

Activin A programs the differentiation of human TFH cells

Ricardo Monterrosa
June 6, 2024

Crotty, Peters, Sette

Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage

Ricardo Monterrosa
June 6, 2024

Crotty, Schoenberger

Effectors and memories: Bcl-6 and Blimp-1 in t and B lyphocyte differentiation

Ricardo Monterrosa
June 6, 2024

Crotty, Peters, Sette

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens

Ricardo Monterrosa
June 6, 2024

Crotty

In vivo regulation of Bcl6 and T follicular helper cell development

Ricardo Monterrosa
June 6, 2024

Crotty

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

Ricardo Monterrosa
June 6, 2024

Crotty

IL-21 and IL-6 are critical for differental aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation

Ricardo Monterrosa
June 6, 2024

Crotty, Kawakami

Protective murine and human monoclonal antibodies against eczema vaccinatum

Ricardo Monterrosa
June 6, 2024

Croft, Crotty, Schoenberger

B cell-specific expression of b7-2 is required for follicular th cell function in response to vaccinia virus

Ricardo Monterrosa
June 6, 2024

Crotty

Follicular helper CD4 T cells (TFH)

Ricardo Monterrosa
June 6, 2024

Crotty

ICSO receptor instructs T follicular helper cells versus effector cell differentiation via induction of the transcriptional reporessor Bcl6

Ricardo Monterrosa
June 6, 2024

Crotty

An epitope conserved in orthopoxvirus A13 envelope protein is the target of neutralizing and protective antibodies

Ricardo Monterrosa
June 6, 2024

Crotty

STAT5 is a potent negative regulator of TFH cell differentiation

Ricardo Monterrosa
June 6, 2024

Crotty

Bcl6 and maf cooperate to instruct human follicular helper CD4 T cell differentiation

Ricardo Monterrosa
June 6, 2024

Crotty

The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development

Ricardo Monterrosa
June 6, 2024

Crotty

The 1-1-1 fallacy

Ricardo Monterrosa
June 6, 2024

Crotty

A blueprint for HIV vaccine discovery

Ricardo Monterrosa
June 6, 2024

Croft, Crotty, Von Herrath

OX40 facilitates control of a persistent virus infection

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Structural and biochemical characterization of the vaccinia virus envelope protein D8 and its recognition by the antibody LA5

Ricardo Monterrosa
June 6, 2024

Crotty

Protection of rabbits and immunodeficient mice against lethal poxvirus infections by human monoclonal antibodies

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine

Ricardo Monterrosa
June 6, 2024

Crotty

Harnessing CD4+ T cell responses in HIV vaccine development

Ricardo Monterrosa
June 6, 2024

Crotty

Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Blc6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory

Ricardo Monterrosa
June 6, 2024

Crotty

Inadequate T follicular cell help impairs B cell immunity during HIV infection

Ricardo Monterrosa
June 6, 2024

Crotty

Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells

Ricardo Monterrosa
June 6, 2024

Crotty

Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination

Ricardo Monterrosa
June 6, 2024

Crotty, Sette

Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIN antibody responses

Ricardo Monterrosa
June 6, 2024

Croft, Crotty, Von Herrath

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts DC4 T cells into the effector lineage by upregulating blimp-1

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Using a combined computational-exterimental approach to predict antibody-specific B cell epitopes

Ricardo Monterrosa
June 6, 2024

Crotty

Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection

Ricardo Monterrosa
June 6, 2024

Crotty

The transcription factor FoxP1 is a critical negative regulator of the differentiation of foccicular helper T cells

Ricardo Monterrosa
June 6, 2024

Crotty

The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells

Ricardo Monterrosa
June 6, 2024

Crotty, Peters, Rao, Sharma

In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation

Ricardo Monterrosa
June 6, 2024

Crotty

T follicular helper cell differentiation, function, and roles in disease

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protien

Ricardo Monterrosa
June 6, 2024

Crotty

The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells

Ricardo Monterrosa
June 6, 2024

Crotty

Retroviral vector expression in TCR transgenic CD4(+) T cells

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E

Ricardo Monterrosa
June 6, 2024

Crotty

A brief history of T cell help to B cells

Ricardo Monterrosa
June 6, 2024

Crotty

In vivo RNAi screens: concepts and applications

Ricardo Monterrosa
June 6, 2024

Crotty

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

Ricardo Monterrosa
June 6, 2024

Crotty

Cutting edge: T follicular helper cell differentiaion is defective in the absence of Bcl6 BTB repressor domain function

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Structural and functional characterization of anti-A33 antibodies reveal a potent cross-species orthopoxviruses neutralizer

Ricardo Monterrosa
June 6, 2024

Crotty, Peters, Sette

Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with portective immunity

Ricardo Monterrosa
June 6, 2024

Crotty

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

Ricardo Monterrosa
June 6, 2024

Crotty

Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity

Ricardo Monterrosa
June 6, 2024

Crotty

Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3

Ricardo Monterrosa
June 6, 2024

Crotty

Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection

Ricardo Monterrosa
June 6, 2024

Crotty

Immunogenicity of stabilized HIV-1 envelope trimmers with reduced exposure of non-neutralizing epitopes

Ricardo Monterrosa
June 6, 2024

Crotty

CXCL13 is a plasma biomarker of germinal center activity

Ricardo Monterrosa
June 6, 2024

Crotty, Rao

Cutting edge: NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Linear epitopes in A27 are targets of protective antibodies induced by vaccination against smallpox

Ricardo Monterrosa
June 6, 2024

Crotty

Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort

Ricardo Monterrosa
June 6, 2024

Crotty, Peters

Linear epitopes in vaccinia virus A27 are targets of protective antibodies induced by vaccination against smallpox

Ricardo Monterrosa
June 6, 2024

Crotty

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Ricardo Monterrosa
June 6, 2024

Crotty

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation

Ricardo Monterrosa
June 6, 2024

Crotty, Peters, Sette

Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunication in adolescence and adulthood

Ricardo Monterrosa
June 6, 2024

Crotty

CRISPR-mediated slamf1Δ/Δ slamf5Δ/Δ slamf6Δ/Δ triple gene disruption reveals NKT cell defects but not T follicular helper cell defects

Ricardo Monterrosa
June 6, 2024

Crotty

Cytokine-independent detection of antigen-specific germinal center T follicular helper cells in immunized nonhuman primates using a live cell activation-induced marker technique

Ricardo Monterrosa
June 6, 2024

Altman, Crotty

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1

Ricardo Monterrosa
June 6, 2024

Crotty, Sette

A cytokine-independent approach to identify antigen-specific human germinal center T follicular helper cells and rare antigen-specific CD4+ T cells in blood

Ricardo Monterrosa
June 6, 2024

Crotty, Sette

Response to comment on “A cytokine-independent approach to identify antigen-specific human germinal center T follicular helper cells and rare antigen-specific CD4+ T cells in blood

Ricardo Monterrosa
June 6, 2024

Crotty

Dances with cytokines, featuring TFH cells, IL-24 and B cells

Ricardo Monterrosa
June 6, 2024

Crotty

Adjuvanting an simian immunodeficiency virus vaccine with toll-like receptor ligands encapsulated in nanoparticles induces persistent antibody responses and enhanced protection in TRIM5α restrictive macaques

Ricardo Monterrosa
June 6, 2024

Crotty, Sette

Definition of human epitopes recognized in tetanus toxoid and development of an assay strategy to detect ex vivo tetanus CD4+ T cell responses

Ricardo Monterrosa
June 6, 2024

Crotty

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

Ricardo Monterrosa
June 6, 2024

Crotty

Sustained antigen availability during ferminal center initiation enhances antibody responses to vaccination

Ricardo Monterrosa
June 6, 2024

Crotty

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation

Ricardo Monterrosa
June 6, 2024

contact@lji.org
9420 Athena Circle
La Jolla, CA 92037

Phone: +1 (858) 752-6500

© 2024 La Jolla Institute for Immunology. All rights reserved. LJI is a 501(c)(3) tax-exempt organization. Federal Tax ID Number 33-0328688