Lab Crotty
Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus
Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins
Germinal center enhancement by extended antigen availability
A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers
Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunication using optimized approaches
Structure-based design of naïve-like HIV-1 envelope trimers to silence non-renutralizing epitopes and eliminate CD4 binding
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells
Raging evolution of a B cell response to a viral infection
The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity
Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis
Do memory CD4 T cells keep their cell-type programming: plasticity versus fate commitment? Complexities of interpretation due to the heterogeneity of memory CD4 T cells including T follicular helper cells
Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques
BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data
Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets
The transcription factor Runx3 establishes chromatin accessibility of cis-regulatory landscapes that drive memory cytotoxic T lymphocyte formation
When designing vaccines, consider the starting material: the human B cell repertoire
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials
Th1/Th17 polarization persists following whole-cell pertussis vaccination dspite repeated acellular boosters
Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
T cell responses to SARS-CoV-2
Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
T follicular helper cell biology: a decade of discovery and diseases
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations
Engineered immunogen binding to alum adjuvant enhances humoral immunity
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
Targeting HIV Env immunogens to B cell follicles in nonhuman primate through immune complex or protein nanoparticle formulations
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo
Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.
HIV vaccinology: 2021 update.
Cross-reactive memory T cells and herd immunity to SARS-CoV-2
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.
Adaptive immunity to SARS-CoV-2 and COVID-19.
Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH).
Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers.
AI-guided discovery of the invariant host response to viral pandemics.
Chronic e-cigarette aerosol inhalation alters the immune state of the lungs and increases ACE2 expression, raising concern for altered response and susceptibility to SARS-CoV-2.
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.
Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals.
SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19.
Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells.
Revealing T follicular helper cells with BCL6.
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells.
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
Phosphate-mediated co-anchoring of RBD immunogens and molecular adjuvants to alum 4 potentiates humoral immunity against SARS-CoV-2
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
From structure to sequence: Antibody discovery using cryoEM
Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study
Memory B cell development after asymptomatic or mile symptomatic SARS-CoV-2 infection
Mpox vaccine and infection-driven human immune signatures
Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cell
The transcription factor YY-1 is an essential regulator of T follicular helper cell differentiation
mmunological memory to SARS-CoV-2 infection and COVID-19 vaccines
Correlates of protection against SARS-CoV-2 infection and COVID-19 disease
Long primed germinal centers with enduring affinity maturation and clonal migration
Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status
Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia
Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients
Humoral and cellular immune memory to four COVID-19 vaccines
Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus
Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8 + T stem cell memory
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to Variants of Concern
Focusing antibody responses to the fusion peptide in rhesus macaques
The chromatin Rregulator Mll1 supports T follicular helper cell differentiation by controlling expression of Bcl6, LEF-1, and TCF-1
Transcriptional programming of CD4+ TRM differentiation in viral infection balances effector- and memory-associated gene expression
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells
Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration
Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates
Early antiviral CD4 and CD8 T cell responses are associated with upper respiratory tract clearance of SARS-CoV-2
Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves
Cytokines in follicular helper T cell Biology in physiologic and pathologic conditions
SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback
Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report
How COVID-19 ‘breakthrough’ infections alter your immune cells
LA JOLLA, CA—New research from scientists at La Jolla Institute for Immunology (LJI) suggests people who received COVID-19 vaccines and then experienced “breakthrough” infections are especially well armed against future SARS-CoV-2 infections.
Ivy Phung works to build better vaccines
How a Ph.D. student found a place in the intense world of HIV vaccine research
La Jolla Institute for Immunology appoints Shane Crotty, PhD, as Chief Scientific Officer
LJI Professor Shane Crotty, PhD, has been appointed Chief Scientific Officer of La Jolla Institute for Immunology (LJI)
