We’ve learned a lot from lymphocytic choriomeningitis virus—now the time has come to fight it
LJI scientists share high-resolution view of the lymphocytic choriomeningitis virus (LCMV) glycoprotein together with a neutralizing antibody
Lab Crotty
Shane Crotty receives AAI-BioLegend Herzenberg Award for B cell research
Crotty has advanced vaccine research and tested new strategies for stopping HIV, COVID-19
LJI scientists reflect on what it means to make the “Highly Cited” list
A record number of LJI researchers have been named to the 2022 list, including two early career scientists
The longer the bootcamp, the better the antibodies
LJI scientists test new vaccine strategy to help the body target HIV
LJI scientists publish first head-to-head comparison of four COVID-19 vaccines
New investigation reveals the strength of T cell, B cell, and antibody responses over time
LJI Professor Shane Crotty elected to the American Academy of Microbiology
“This is a real honor. The ASM is an outstanding organization.”
Current vaccines teach T cells to fight Omicron
New LJI study shows how the fully vaccinated respond to a range of SARS-CoV-2 variants
New vaccine ingredient shows promise
Most vaccines include particles called adjuvants. But not all adjuvants are created equal.
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
Lungs of COVID-19 survivors teem with virus-fighting ‘memory’ cells
Even elderly survivors show a strong, persistent immune memory
Moderna COVID-19 vaccine spurs lasting immune response
Immune system memory stays strong 6+ months post-vaccination, similar to responses in recovered COVID-19 patients
Shane Crotty achieves “World Expert” status for vaccine research
Professor Shane Crotty, Ph.D. , of the La Jolla Institute for Immunology (LJI), has earned the distinction of “World Expert” in vaccine research. This ranking is based on Expertscape‘s PubMed-based algorithms, which place Crotty in the top 0.1% of scholars publishing information…
Can we stretch existing Covid vaccines to inoculate more people? Experts are divided
With the global supply of Covid-19 vaccine still woefully inadequate, vaccine makers are scouring the pharmaceutical landscape for partners to ramp up manufacturing
Sydney Ramirez investigates a lingering COVID-19 question
New A.P. Giannini Foundation Fellowship opens the door to an in-depth look at SARS-CoV-2 infections
In-Depth: San Diego’s most influential COVID-19 researchers
Throughout the pandemic, scientists in San Diego have made big contributions
In-Depth: La Jolla Institute takes comprehensive look at COVID-19 immunity
Study compares four vaccines and natural immunity
In mutant variants, has the coronavirus shown its best tricks?
The rapid rise in different parts of the world of deadly, more infectious coronavirus variants that share new mutations is leading scientists to ask a critical question
The Shapeshifting Virus
Coronavirus: The Evidence
The Future of the Coronavirus? An Annoying Childhood Infection
Once immunity is widespread in adults, the virus rampaging across the world will come to resemble the common cold, scientists predict.
Covid-19 immunity likely lasts for years
A new study shows immune cells primed to fight the coronavirus should persist for a long time after someone is vaccinated or recovers from infection.
Protective immunity against SARS-CoV-2 could last eight months or more
Why declining antibodies don't spell disaster for long-lasting immunity
Inside the labs of three leading San Diego scientists
LJI Professors Shane Crotty, Ph.D., Bjoern Peters, Ph.D., and Alessandro Sette, Dr. Biol. Sci., were named “Highly Cited Researchers” this week by Clarivate.
The End of the Pandemic Is Now in Sight
A year of scientific uncertainty is over. Two vaccines look like they will work, and more should follow.
Immunity to the Coronavirus May Last Years, New Data Hint
Blood samples from recovered patients suggest a powerful, long-lasting immune response, researchers reported.
Coronavirus Immunity May Last Years, Possibly Even Decades, Study Suggests
Immunity to the novel coronavirus may last eight months or longer, according to a new study authored by respected scientists at leading labs, which found that individuals who recovered from the coronavirus developed “robust” levels of B cells and T cells (necessary for fighting off the virus) and “these cells may persist in the body for a very, very long time.”
T cells take the lead in controlling SARS-CoV-2 and reducing COVID-19 disease severity
Finding may help explain why people 65 and above face a higher risk of falling critically ill with COVID-19
Beating HIV and COVID-19 may depend on tweaking vaccine molecules
LJI and Scripps Research scientists tackle the problem of antigen valency
Forty percent of people with coronavirus infections have no symptoms. Might they be the key to ending the pandemic?
New research suggests that some of us may be partially protected due to past encounters with common cold coronaviruses
Immunology Is Where Intuition Goes to Die
Which is too bad because we really need to understand how the immune system reacts to the coronavirus.
Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2
Researchers caution: It is too soon to say whether pre-existing immune cell memory affects COVID-19 clinical outcomes
Do some people have protection against the coronavirus?
We’re now more than seven months into the coronavirus pandemic that has upended the lives of most of Earth’s inhabitants.
Concerns about Waning COVID-19 Immunity Are Likely Overblown
The decline seen in some studies is normal, experts say. But scientists must wait to see whether infection confers long-term protection
Designing Vaccines: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh Cells)
A video lecture on Tfh cell biology can be seen here. Germinal centers are the critical sites for the development of long term humoral immunity in the form of antigen-specific memory B lymphocytes and long-lived plasma cells. CD4 T cells…
HIV Vaccine Research (AIDS Vaccine Research)
Broadly neutralizing antibodies have been discovered in ~5% of HIV+ individuals. Some of those antibodies (HIV bnAbs) are capable of neutralizing over 70% of all known HIV isolates. Finally, providing a single intravenous injection of a single HIV bnAb into…
Even in the worst COVID-19 cases, the body launches immune cells to fight back
International collaboration provides important piece of COVID-19 puzzle
LJI scientists investigate a powerful protein behind antibody development
The new study shows how a protein works as a “master regulator” in the immune system
First detailed analysis of immune response to SARS-CoV-2 bodes well for COVID-19 vaccine development
Study finds robust antiviral T cell response in humans with COVID-19 and detects substantial crossreactivity in unexposed individuals; in a piece of good news provides a benchmark for testing of vaccine candidates.
AAAS and La Jolla Institute for Immunology announce 2019 Fellows
Professors Shane Crotty, Ph.D., and Alessandro Sette, Dr. Biol.Sci., of La Jolla Institute for Immunology have been named as AAAS Fellows
Groundbreaking HIV vaccine design strategy shows promise in proof-of-principle tests
A new approach that targets young immune cells may also work for creating vaccines against the flu, dengue, malaria and hepatitis C
Dr. Shane Crotty honored with 2019 Frederick W. Alt Award for New Discoveries in Immunology
The award is given annually to a former Cancer Research Institute postdoctoral fellow in recognition of outstanding success in academia or industry for research that has had a major impact in the field of immunology.
New HIV vaccine strategy “pumps” the immune system
LJI scientists find that slowly releasing an HIV vaccine could prompt the body to make more powerful antibodies against the virus
Why your kid’s strep throat keeps coming back
A combination of genetic and immunological factors makes some children susceptible to the bacteria that cause strep throat
