Lab Hedrick
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C(-) monocytes
Monocyte and macrophage dynamics during atherogenesis
Accelerated atherosclerosis in apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis
ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development
Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia
Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially reguates their activationIncreased cholesterol content in gammadelta (γδ) T lymphocytes differentially reguates their activation
Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal
NR4A nuclear receptors in immunity and atherosclerosis
Myeloid cells in atherosclerosis: a delicate balance of anti-inflammatory and proinflammatory mechanisms
Stressing out stem cells: linking stress and hematopoiesis in cardiovascular disease
Gammadelta (ϒδ) T lymphocytes do not impact the development of early atheroscherosis
Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in infarcted myocardium
IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
Monocyte phenotypes: when local education counts
The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3
Lymphocytes in atherosclerosis
The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus
Nonclassical patrolling monocyte function in the vasculature
Cardif (MAVS) regulates the maturation of NK cells
Patrolling monocytes control tumor metastasis to the lung
Cutting edge: the orphan nuclear receptor Nr4a1 regulates CD8+ T cell expansion and effector function through direct repression of Irf4
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
Transcriptional control of monocyte development
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis
ATP binding cassette transporter ABCA7 regulates NKT cell development and function by controlling CD1d expression and lipid raft content
Human blood monocyte subsets: a new gating strategy defined using cell surface markers identified by mass cytometry
Scavenger receptor CD36 directs nonclassical monocyte patrolling along the endothelium during early atherogenesis
Patrolling mechanics of non-classical monocytes in vascular inflammation
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis
Understanding the tumor immune microenvironment (TIME) for effective therapy
Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry
Human monocyte heterogeneity as revealed by high-dimensional mass cytometry
Neutrophils: New insights and open questions
Monocyte heterogeneity and functions in cancer
Nonclassical monocytes in health and disease
Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease
Patrolling Monocytes Control NK Cell Expression of Activating and Stimulatory Receptors to Curtail Lung Metastases
Neuropilin-1 expression on CD4 T cells is atherogenic and facilitates T cell migration to the aorta in atherosclerosis
Perivascular Localization of Macrophages in the Intestinal Mucosa Is Regulated by Nr4a1 and the Microbiome
Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression.
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100-Reactive CD4 + T-Regulatory Cells
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance
CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage.
Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4(+) T-Regulatory Cells
Nonclassical monocytes (CD14dimCD16+) are associated with carotid intima-media thickness progression for men but not women: the multi-ethnic study of atherosclerosis-brief report.
Neutrophils in cancer: heterogeneous and multifaceted.
Atherosclerosis impairs naive CD4 T-cell responses via disruption of glycolysis.
The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy.
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.
Flow Cytometry and Mass Cytometry for Measuring the Immune Cell Infiltrate in Atherosclerotic Arteries
Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice.
CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer
Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization
Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation
Identification of an early unipotent neutrophil progenitor with pro-tumoral activity in mouse and human bone marrow
Lynn Hedrick and Klaus Ley named “World Experts” in monocyte research
Immune cells called monocytes offer clues to treating cancers, heart disease and more
Lynn Hedrick receives more than $500,000 for COVID-19 research
New immune cell studies may shed light on heart attacks, inflammation seen in COVID-19 patients
LJI team gets first-ever look at a rare but vital stem cell in humans
New understanding of immune cell origins may offer cancer and COVID-19 drug targets
