Lab Hogan
Yue Zhao
Patrick Hogan
Hannah Drum
Arlet Lara Custodio
Barsha Dash
STIM1 gates the store-operated calcium channel ORAI1 in vitro
Molecular basis of calcium signalling in lymphocytes: STIM and ORAI
Pore architecture of the ORAI1 store-operated calcium channel
Interaction of calcineurin with substrates and targeting proteins
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling
Insights into CRAC channel gating and ion permeation
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry
Initial activation of STIM1, the regulator of store-operated calcium entry
STIM-ORAI interactions that control the CRAC channel
ORAI1 calcium channel orchestrates skin homeostasis
Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction
STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel
Store-operated calcium entry: mechanisms and modulation
Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling
The STIM1-ORAI1 microdomain
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation
TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling
The STIM-orai pathway: orai, the pore-forming subunit of the CRAC channel
Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells
Calcium-NFAT transcriptional signalling in T cell activation and T cell exhaustion
Transcriptional and epigenetic regulation of T cell hyporesponsiveness
Coiled-coil formation conveys a STIM1 signal from ER lumen to cytoplasm
A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure
Calcium sensing by the STIM1 ER-luminal domain
STIM calcium sensing and conformational change
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling
Defining ‘T cell exhaustion’
Calcineurin: a star is reborn.
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
Calcium signals regulate the functional differentiation of thymic iNKT cells.
TET2, tumor control, and CAR T cell hyperproliferation
Time-motion observations to characterize the developmental environment in a paediatric post-acute care hospital
The road not taken en route to T cell exhaustion
Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput
The Reappraisal of the Reappraisal-CRAC Channels Are Activated by L-Type Ca2+ Channel Blockers, Reply to Bird et al
Roberta Nowak, lab manager extraordinaire
A "Lab Manager of the Year" finalist shares tips for keeping research running—and scientists happy
Preparing T cells for the long haul
New LJI research could keep cancer-fighting T cells from burning out before the job is done
To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT
Chemical screen proves feasibility of modulating factor at the hub of immune system's decision to attack or retreat
Scientists devise strategies to counteract T cell exhaustion in CAR T cancer therapies
La Jolla Institute scientists show that deleting troublesome proteins in a mouse model can shrink tumors and prolong survival
