Lab Kawakami
FcepsilonRI beta-chain ITAM amplifies P13K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors
Tyrosine phosphorylation of SHIP promotes its proteasomal degradation
Monomeric IgE and mast cell development, survival and function
SHIP represses Th2 skewing by inhibiting IL-4 production from basophils
Lyn- and PLC-{beta}3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
JNK1 controls mast cell degranulation and IL-1{beta}production in inflammatory arthritis
Protective murine and human monoclonal antibodies against eczema vaccinatum
Phospholipase C-β3 regulates FcεRI-mediated mast cell activation by recruiting the proteinphosphatase SHP-1
Short stat5-interacting peptide derived from phospholipase C-β3 inhits hematopoietic cell proliferation and myeloid differentiation
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice
Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase
Omalizumab inhibits acceleration of FceRI-mediated responsiveness of immature human mast cells by immunoglobulin EOmalizumab inhibits acceleration of FceRI-mediated responsiveness of immature human mast cells by immunoglobulin EOmalizumab inhibits acceleration of FceRI-mediated responsiveness of immature human mast cells by immunoglobulin EOmalizumab inhibits acceleration of FceRI-mediated responsiveness of immature human mast cells by immunoglobulin E
Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy
The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and protein L
Human FcyRIIA at center stage
Editorial: Histamine-releasing factor and TCTP
HRF-interacting molecules
A novel role of the transcription factor HIF-1α in the formation of mast cell extracellular traps
Most highly cytokinergic IgEs have polyreactivity to autoantigens
Immune regulation by phospholipase C-β isoforms
Phospholipase C-β in immune cells
Salmonella’s masterful skill in mast cell suppression
Critical role for mast cell stat5 activity in skin inflammation
Histimine-releasing factor and immunoglobulins in asthma and allergy
Basic techniques to study FcεRI signaling in mast cells
A mouse model of atopic dermatitis
Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation
Hypothetical atopic dermatitis-myeloproliferative neoplasm syndrome
Signal transduction and chemotaxis in mast cells
Differentiate or die!
Role of histamine-releasing factor in allergic inflammatory reactions
Skin microbiome promotes mast cell maturation by triggering stem cell factor (SCF) production in keratinocytes
Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes
Defective natural killer cell activity in a mouse model of eczema herpeticum
TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis
Histamine-releasing factor enhances food allergy
LIGHT-HVEM signaling in keratinocytes controls development of dermatitis
Crystal structures of murine and human histamine-releasing factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation
PAI1 mediates fibroblast-mast cell interactions in skin fibrosis
Mouse body temperature measurement using infrared thermometer during passive systemic anaphylaxis and food allergy evaluation
Awaiting allograft antigen: For rejection or tolerance?
The basophil-IL-4-mast cell axis is required for food allergy
Histamine-Releasing Factor, a New Therapeutic Target in Allergic Diseases
Anaphylactic or tolerant outcomes with IgE
Anaphylactic or tolerant outcomes with IgE.
Recent advances in mast cell activation and regulation.
Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.
The high affinity IgE receptor: a signaling update.
Role of TCTP in cell biological and disease processes.
Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation
Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment
A leader in allergy research retires
LJI Professor Emeritus Toshiaki Kawakami, M.D., Ph.D., uncovered the molecular underpinnings of allergy, tumor responses, and more
Blocking immune system ‘messenger’ may treat severe asthma
Finally beating asthma might hinge on blocking HRF and IgE interactions
Mouse Model of Atopic Dermatitis (AD)
As our knowledge of the FceRI-mediated signal transduction has grown for the last two decades, the need to study in vivo roles of this pathway in disease settings encouraged the Kawakami group to develop novel in vivo models of allergic…
Phospholipase C (PLC)-B3-Mediated Regulation of Stat5 Activity
Given their previous studies on crosstalks between PTKs-dependent and G protein-coupled receptor-dependent signals in FceRI-stimulated mast cells, they have been characterizing PLC-b isoforms. In addition to its role in an early FceRI signal transduction, they found that deficiency in PLC-b3…
IgE Heterogeneity
Since their finding of ‘monomeric IgE effects’ on mast cell survival in 2001, Dr. Kawakami and associates have shown that IgEs exhibit a tremendous heterogeneity in their ability to induce mast cell activation, with highly cytokinergic (HC) IgEs at one…
Bruton’s Tyrosine Kinase (Btk) in Mast Cell Activation
Dr. Kawakami has been using the high-affinity IgE receptor (FceRI) signaling in mast cells as a model system. Following his co-discovery of two Tec family PTKs, Btk and Itk, in mast cells, his group revealed crucial roles of these kinases…
Btk-Mediated Regulation of Cytokine Production
During the course of the above-mentioned study, they found interactions between Btk and protein kinase C (PKC)-b and terreic acid as a novel Btk inhibitor that blocked Btk-PKC-b interactions. Their study also showed that PKC-b and Akt are essential for…
