Lab Kronenberg
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
The protein phosphatase Shp1 regulates invariant NKT cell effector differentiation independently of TCR and slam signaling
The HVEM-BTLA axis restrains T cell help to germinal center B cells and functions as a cell-extrinsic suppressor in lymphomagenesis
SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model
Publisher Correction: Innate-like functions of natural killer T cell subsets result from highly divergent gene programs
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Bacterial Infection Allows for Functional Examination of Adoptively Transferred Mouse Innate Lymphoid Cell Subsets
The role of innate lymphoid cells in response to microbes at mucosal surfaces
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants.
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils.
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis.
Calcium signals regulate the functional differentiation of thymic iNKT cells.
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
Thymus-derived CD4+CD8+ cells reside in mediastinal adipose tissue and the aortic arch.
Stimulation of a subset of natural killer T cells by CD103+ DC is required for GM-CSF and protection from pneumococcal infection.
Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity.
The ImmGen consortium OpenSource T cell project.
Impact of genetic polymorphisms on human immune cell gene expression
Innate-like functions of natural killer T cell subsets result from highly divergent programs
Innate-like T cells: connecting the dots linking microscopic intestinal inflammation to spondyloarthritis
Sars-cov-2 omicron (b.1.1.529) shows minimal neurotropism in a double-humanized mouse model.
Intravital imaging of intestinal intraepithelial lymphocytes
Integrative scatac-seq and scrna-seq analyses map thymic inkt cell development and identify cbfbeta for its commitment
Divergent metabolic programmes control two populations of mait cells that protect the lung
A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor alpha determines t cell activation and function
Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: Results from a latin american andean cohort
A sensitive and integrated approach to profile messenger RNA from samples with low cell numbers
A closer look at rebel T cells
LJI researchers investigate a group of T cells known for their unusual response to pathogens
Powerhouses
LJI's Immunometabolism Core gives researchers a closer look at how cells gather energy to fight disease
Can sugar and fat influence immune cell responses?
LJI scientists find MAIT cells can be tuned to fight different pathogens via their metabolism, paving the way for new therapeutic strategies
The gut patrol
A fascinating new look at what drives T cells to guard the intestines
Stopping lung damage before it turns deadly
LJI scientists discover new drug target for severe asthma, fibrosis
LJI graduate students win prestigious ARCS San Diego awards
ARCS support propels vaccine design and HIV research
NKT Cell Immunology
Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.…
Mucosal Immunology and IBD
A major area of research in our laboratory is the regulation of mucosal immunity. We have collaborated extensively with the Hilde Cheroutre laboratory at our Institute on several projects, including investigation of the function of intestinal intraepithelial lymphocytes (IEL), particularly…
Dr. Mitchell Kronenberg elected Distinguished Fellow by the American Association of Immunologists
Dr. Kronenberg is among 52 immunologists, including five Nobel Laureates, selected for the inaugural class of fellows
