New research points to ‘stem-like’ T cells as culprits in ulcerative colitis

Jun 19, 2024 Research News

New research points to ‘stem-like’ T cells as culprits in ulcerative colitis

LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have shed light on how an unusual population of T

Nov 15, 2023 Front Med (Lausanne)

Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: Results from a latin american andean cohort

Perez-Jeldres T, Magne F, Ascui G, Alvares D, Orellana M, Alvarez-Lobos M, Hernandez-Rocha C, Azocar L, Aguilar N, Espino A, Estela R, Escobar S, Zazueta A, Baez P, Silva V, De La Vega A, Arriagada E, Pavez-Ovalle C, Diaz-Asencio A, Travisany D, Miquel JF, Villablanca EJ, Kronenberg M, Bustamante ML

Nov 10, 2023 Sci Immunol

Transcriptomes and metabolism define mouse and human mait cell populations

Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramirez-Suastegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M

Nov 1, 2023 Arthritis Rheumatol

Innate-like T cells: connecting the dots linking microscopic intestinal inflammation to spondyloarthritis

Zhao M, Kronenberg M

Sep 12, 2023 Immunity

A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor alpha determines t cell activation and function

Larange A, Takazawa I, Kakugawa K, Thiault N, Ngoi S, Olive ME, Iwaya H, Seguin L, Vicente-Suarez I, Becart S, Verstichel G, Balancio A, Altman A, Chang JT, Taniuchi I, Lillemeier B, Kronenberg M, Myers SA, Cheroutre H

Jul 24, 2023 Arthritis Rheumatol

Innate-like T cells: connecting the dots linking microscopic intestinal inflammation to spondyloarthritis

Zhao M, Kronenberg M

Jul 20, 2023 Bio Protoc

Intravital imaging of intestinal intraepithelial lymphocytes

McArdle S, Seo GY, Kronenberg M, Mikulski Z

Nov 10, 2023 Research News

A closer look at rebel T cells

LJI researchers investigate a group of T cells known for their unusual response to pathogens

Jun 1, 2023 Nat Cell Biol

Divergent metabolic programmes control two populations of mait cells that protect the lung

Riffelmacher T, Paynich Murray M, Wientjens C, Chandra S, Cedillo-Castelan V, Chou TF, McArdle S, Dillingham C, Devereaux J, Nilsen A, Brunel S, Lewinsohn DM, Hasty J, Seumois G, Benedict CA, Vijayanand P, Kronenberg M

Jun 20, 2023 Cell Discov

Integrative scatac-seq and scrna-seq analyses map thymic inkt cell development and identify cbfbeta for its commitment

Wang J, Adrianto I, Subedi K, Liu T, Wu X, Yi Q, Loveless I, Yin C, Datta I, Sant'Angelo DB, Kronenberg M, Zhou L, Mi QS

Apr 1, 2023 Antiviral Res

SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model

Alves RPDS, Wang YT, Mikulski Z, McArdle S, Shafee N, Valentine KM, Miller R, Verma SK, Batiz FAS, Maule E, Nguyen MN, Timis J, Mann C, Zandonatti M, Alarcon S, Rowe J, Kronenberg M, Weiskopf D, Sette A, Hastie K, Saphire EO, Festin S, Kim K, Shresta S

Jun 15, 2023 Behind the Science

Powerhouses

LJI's Immunometabolism Core gives researchers a closer look at how cells gather energy to fight disease