Lab Peters
Circulating T cell-monocyte complexes are markers of immune perturbations
Immunoinformatics: Predicting peptide-MHC binding
Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium
Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection
Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles
T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
IEDB and CEDAR: two sibling databases to serve the global scientific community
Machine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
An integrated workflow to assess technical and biological variability of cell population frequencies in human peripheral blood by flow cytometry
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants
The megapool approach to characterize adaptive CD4+ and CD8+ T cell responses
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children
Early antiviral CD4 and CD8 T cell responses are associated with upper respiratory tract clearance of SARS-CoV-2
Corrigendum to “Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study” [eBioMedicine 83 (2022) 104208]
A multi-omics systems vaccinology resource to develop and test computational models of immunity
Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology
Proteome Analysis for Inflammation Related to Acute and Convalescent Infection
Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
PEPMatch: a tool to identify short peptide sequence matches in large sets of proteins
Vac to the future
Vaccine researchers take on the challenge of predicting B. pertussis immunization outcomes
A step toward personalized immunotherapy for all
Scientists find evidence that all cancer patients mount an immune response to their tumors, suggesting that many more patients could benefit from personalized immunotherapy
New $17 million grant establishes LJI as global hub for immunology data curation and analysis
NIAID support opens gateway to new research into human immune responses to viruses, the development of autoimmune diseases, and more
LJI scientists reflect on what it means to make the “Highly Cited” list
A record number of LJI researchers have been named to the 2022 list, including two early career scientists
Graduate student Leila Chihab wins prestigious NSF grant
Chihab explores how T cells find and kill tumors
The Conrad Prebys Foundation grants more than $1.5 million to support critical infrastructure—and a fascinating branch of immunology
"This support allows LJI scientists to buy essential equipment and pursue fascinating early career research."
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
LJI launches new global cancer immunology resource
National Cancer Institute support brings cancer researchers together to share key findings
Q&A with Bjoern Peters, Ph.D.
The bioinformatics tools Dr. Peters has developed are invaluable for immunologists worldwide.
Inside the labs of three leading San Diego scientists
LJI Professors Shane Crotty, Ph.D., Bjoern Peters, Ph.D., and Alessandro Sette, Dr. Biol. Sci., were named “Highly Cited Researchers” this week by Clarivate.
New look at COVID-19 cases does not support link between BCG vaccination and lower mortality
COVID-carrying skiers may help explain disease trends in Germany
Tuberculosis
Investigation of human immune signatures of latent MTB infection, active disease and BCG vaccination. (NIH/NIAID, U19 AI118626) Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection. (NIH/NIAID, 75N93019C00067) Goal: To define MTB-derived T cell epitopes…
Whooping Cough
Research to identify mechanisms and correlates of long-lasting vaccine-induced immunity to whooping cough. The lab aims to define transcriptional responses to vaccine boost from donors originally primed with aP vs. wP and identify cell types associated with differential responses, as…
Allergic Diseases
Pediatric Milk Allergy: To study the frequency and phenotype of milk allergen-specific T cells in cohorts with different disease manifestations and define molecular markers of disease status and progression to tolerance. This research will contribute to developing improved and new…
Epigenetic and Transcriptomic Profile of Human Immune Cells
The lab aims to perform epigenetic and transcriptomic analyses of purified circulating immune cell types from healthy human subjects. NIH/NIAID (R24AI08564)
Data Standards
HIPC Data Standards: A collaboration with various centers of the Human Immune Profiling Consortium (HIPC) to build upon the existing infrastructure of ImmPort, a publicly-available data repository, which includes standardization of defined data elements such as immune exposures, including vaccinations,…
SARS-COV-2
COVIC-DB: To co-run the LJI-led CoVIC database in the effort to find ideal therapeutic combinations for the novel coronavirus, the assays that best predict efficacy, and the features that provide protection. Coronavirus Immunotherapy Consortium (CoVIC) CoVIC Database Supported by the…
Cancer
Immunotherapies for head and neck cancer: To develop new cancer therapies by studying how the immune system, by way of neo-antigens, can recognize and eliminate tumor cells by targeting molecules only found on the surface of the tumor cells. The…
Human Immune Profiling Consortium
The aim of this work, in collaboration with Bjoern Peters, Ph.D., and Pandurangan Vijayanand, M.D., Ph.D., is to characterize the immune response to dengue virus (DENV) and Mycobacterium tuberculosis (MTB), both of which represent major global health challenges. Specifically, the…
Global Highly Cited Researchers 2019 list reveals top scientific talent
This year’s list features four scientists at La Jolla Institute for Immunology
No cell is an island
LJI team finds that ‘doublet’ immune cells are much more common—and more important in disease—than previously thought
La Jolla Institute awarded renewal of NIH contract to continue its role as host of Immune Epitope Database
The IEDB gives biomedical researchers worldwide free access to a rapidly growing catalogue of epitopes—the specific, molecular structures that the immune system uses to tell friend from foe
LJI researcher successfully competes for Intersect Fellowship by the American Association of Immunologists
The fellowship specifically supports interdisciplinary training to encourage understanding between immunology researchers and computational scientists
