Lab Rao
TET methylcytosine oxidases: new insights from a decade of research
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells
TET family dioxygenases and the TET activator vitamin C in immune responses and cancer
Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides.
DNA translocation through vertically stacked 2D layers of graphene and hexagonal boron nitride heterostructure nanopore.
5-azacytidine transiently restores dysregulated erythroid differentiation gene expression in TET2-deficient erythroleukemia cells.
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells.
Whole-genome analysis of TET dioxygenase function in regulatory T cells.
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety.
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation
Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3
Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch
Impact of genetic polymorphisms on human immune cell gene expression
Active DNA demethylation damages DNA
PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors.
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy
LJI scientists develop new method to match genes to their molecular ‘switches’
New research may help scientists hunt down solid tumors and better diagnose disease
LJI scientists solve the mystery of why OGT enzyme is critical for cell survival
New findings open door to better understanding cancers and many other diseases
On the trail of missing genes and cancer clues
LJI scientists connect TET loss of function to missing genes in embryonic stem cells
Strange DNA structures may drive cancer development
LJI researchers shed light on the role of TET enzymes in genomic stability and cancers
Roberta Nowak, lab manager extraordinaire
A "Lab Manager of the Year" finalist shares tips for keeping research running—and scientists happy
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
The early bird
"I always wanted to go into medicine, but there aren’t a lot of ways to enter the field as a 15 year old."
C is for Vitamin C—a key ingredient for immune cell function
Harnessing the combined power of Vitamin C and TET proteins may give scientists a leg up in treating autoimmune diseases
Preparing T cells for the long haul
New LJI research could keep cancer-fighting T cells from burning out before the job is done
Hard-working enzyme keeps immune cells in line
LJI scientists develop new tool for understanding enzymatic activity linked to blood cancers and heart disease
Timothy Baffi receives ACS award to study acute myeloid leukemia
New support from the American Cancer Society fuels research into the primary mutations behind many cancer types
A cancer without a cause
Testing for breast and ovarian cancers has come a long way—but at-risk patients still fall through the cracks. LJI scientist Anup Kumar Singh has won funding to learn more about cancer-causing mutations.
LJI researchers reveal unexpected versatility of an ancient DNA repair factor
Based on its history, HMCES could be the most important protein you've never heard of
TET proteins: double agents in DNA methylation prevent catastrophic cancer
LJI researchers reveal how the finely tuned balance between DNA methylation and demethylation prevents genomic instability and cancer
TET gene mutations in T regulatory cells unleash fatal autoimmune disease in mice
New study reveals how a subset of T cells morphs from peacemaker to rabble-rouser when TET activity is lost
LJI investigators reveal that TET proteins regulate factors essential for normal antibody production
New study sheds light on what goes awry in malignancies marked by TET mutation
Scientists devise strategies to counteract T cell exhaustion in CAR T cancer therapies
La Jolla Institute scientists show that deleting troublesome proteins in a mouse model can shrink tumors and prolong survival
