Postdoctoral Fellow Rachel Helms, Ph.D., awarded 2024 CRI Irvington Postdoctoral Fellowship

Sep 10, 2024 Behind the Science

Postdoctoral Fellow Rachel Helms, Ph.D., awarded 2024 CRI Irvington Postdoctoral Fellowship

LJI scientist aims to answer fundamental questions about the development and maintenance of immune cells to prevent cancer

Jun 3, 2024 Research News

LJI scientists develop new method to match genes to their molecular ‘switches’

New research may help scientists hunt down solid tumors and better diagnose disease

Feb 15, 2024 Annu Rev Immunol

TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer

López-Moyado IF, Ko M, Hogan PG, Rao A.

Feb 15, 2024 Cell Chem Biol

Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy

Ehinger E, Rao A.

Sep 12, 2023 Proc Natl Acad Sci U S A.

TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors.

Gonzalez EA, Liu Y, Wang D, Jeziorek M, Bandyopadhyay S, Rao A, Gao N, Etchegaray JP.

May 30, 2023 Cell Rep.

PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM.

Feb 7, 2023 PNAS

Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

Yuita H, López-Moyado IF, Jeong H, Cheng AX, Scott-Browne J, An J, Nakayama T, Onodera A, Ko M, Rao A.

Jan 17, 2023 PNAS

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

Li X, Yue X, Sepulveda H, Burt RA, Scott DA, A Carr S, A Myers S, Rao A.

Jan 17, 2023 PNAS

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

Li X, Yue X, Sepulveda H, Burt RA, Scott DA, A Carr S, A Myers S, Rao A.

Jan 11, 2023 Research News

LJI scientists solve the mystery of why OGT enzyme is critical for cell survival

LA JOLLA, CA — Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called

Apr 1, 2022 Genes Dev.

HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation

Wu L, Shukla V, Yadavalli AD, Dinesh RK, Xu D, Rao A, Schatz DG.

Oct 1, 2022 Nat Commun.

Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

Georges RO, Sepulveda H, Angel JC, Johnson E, Palomino S, Nowak RB, Desai A, López-Moyado IF, Rao A.