Lab Reina
T cells rise up to fight infections in the gut
Scientists show how a special group of T cells travels through the small intestine to combat pathogens
Cancer researcher Miguel Reina-Campos awarded $1.3 million from W. M. Keck Foundation
LJI lab looks to "boost" cancer-fighting T cells
New Prebys Foundation grant supports LJI mission to train the next generation of researchers
With this new $300,000 grant, LJI Assistant Professor Miguel Reina-Campos, Ph.D., sets out to make scientific training more accessible
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
Metabolism shapes the tumor microenvironment
The complexity of the serine glycine one-carbon pathway in cancer
How is the tissue context enabling TRM-driven immunity?
Spatial transcriptomics at single-molecule resolution allows in situ measurements of hundreds to thousands of genes in large areas of tissues, allowing an unprecedented view into the secret life of TRM. Combined with multiparametric immunohistochemistry technologies, these state-of-the-art approaches enable us…
How can we enhance tissue immunity?
As the mechanistic principles guiding tissue immunity unfold, the Reina Laboratory will focus on leveraging immune engineering technologies to enhance CD8 T cell functions in disease settings to unlock the next generation of immunotherapies. We will devise approaches to: A.…
What are the tissue-specific intrinsic adaptations of TRM?
Long-term tissue residency is a complex, context-dependent challenge requiring specific cellular adaptation strategies. Our recent work has identified common metabolic adaptations that empower CD8 T cell tissue residency and anti-tumor immunity (Reina-Campos et al, Nature 2023), opening exciting new research…
Ácido zaragócico: del hallazgo del hongo ‘del colesterol’ a revelar claves del cáncer
Fue hallado en un hongo del Jalón, como santo grial del colesterol, pero la industria lo abandonó. ¿Se ha redescubierto
Charged up T cells take on tumors in UCSD lab
T cells that reside in human tissue are little watchdogs that live in your lungs, your skin or your gut,
Cancer-killing T-cells are getting help from San Diego researchers
Papers from La Jolla Institution for Immunology and UCSD show innovative ways that key immune system fighters can be made
