A step toward personalized immunotherapy for all

Feb 28, 2024 Research News

A step toward personalized immunotherapy for all

"The potential for a 'cure from within' is in every cancer patient we've looked at..."

Jan 1, 2023 J Immunother Cancer

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model

Shankara Narayanan JS, Hayashi T, Erdem S, McArdle S, Tiriac H, Ray P, Pu M, Mikulski Z, Miller A, Messer K, Carson D, Schoenberger S, White RR.

Sep 1, 2023 Research News

LJI scientists harness ‘helper’ T cells to treat tumors

New preclinical research shows researchers how to give CD4+ and CD8+ T cells more cancer-fighting power

May 5, 2023 bioRxiv

Linked CD4 + /CD8 + T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

Joseph S Dolina, Joey Lee, Spencer E Brightman, Sara McArdle, Samantha M Hall, Rukman R Thota, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Jason A Greenbaum, Ezra E W Cohen, Bjoern Peters, Stephen P Schoenberger

May 7, 2023 bioRxiv

Linked CD4 + /CD8 + T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

Dolina JS, Lee J, Brightman SE, McArdle S, Hall SM, Thota RR, Lanka M, Premlal ALR, Greenbaum JA, Cohen EEW, Peters B, Schoenberger SP

May 30, 2023 Cell Rep

Human papillomavirus e5 suppresses immunity via inhibition of the immunoproteasome and sting pathway

Miyauchi S, Kim SS, Jones RN, Zhang L, Guram K, Sharma S, Schoenberger SP, Cohen EEW, Califano JA, Sharabi AB

Mar 3, 2023 Nat Immunol

Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors

Brightman SE, Becker A, Thota RR, Naradikian MS, Chihab L, Zavala KS, Griswold RQ, Dolina JS, Cohen EEW, Miller AM, Peters B, Schoenberger SP

Jan 6, 2023 Nucleic Acids Res

The cancer epitope database and analysis resource: a blueprint for the establishment of a new bioinformatics resource for use by the cancer immunology community.

Koşaloğlu-Yalçın Z, Blazeska N, Carter H, Nielsen M, Cohen E, Kufe D, Conejo-Garcia J, Robbins P, Schoenberger SP, Peters B, Sette A.

Schoenberger

A step toward personalized immunotherapy for all

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model

LJI scientists harness ‘helper’ T cells to treat tumors

Linked CD4 + /CD8 + T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

Linked CD4 + /CD8 + T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

Human papillomavirus e5 suppresses immunity via inhibition of the immunoproteasome and sting pathway

Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors

The Cancer Epitope Database and Analysis Resource (CEDAR)

Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions

Developmentally distinct CD4 + T reg lineages shape the CD8 + T cell response to acute Listeria infection

Single-cell analysis of immune repertoires enabled.

The cancer epitope database and analysis resource: a blueprint for the establishment of a new bioinformatics resource for use by the cancer immunology community.