Lab Sette
Antigenic determinants of SARS-CoV-2-specific CD4+ T cell lines reveals M protein-driven dysregulation of interferon signaling
T cells in multisystem inflammatory syndrome in children (MIS-C) have a predominant CD4+ T helper response to SARS-CoV-2 peptides and numerous virus-specific CD4- CD8-double-negative T cells
Early and polyantigenic CD4 T cell responses correlate with mild disease in acute COVID-19 donors
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine
Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells
Observations and perspectives on adaptive immunity to SARS-CoV-2
High-resolution analysis of individual spike peptide-specific CD4+ T-cell responses in vaccine recipients and COVID-19 patients.
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes
Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with Immune mediated inflammatory diseases
IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic
Post-acute sequelae and adaptive immune responses in people living with HIV recovering from SARS-COV-2 infection
Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
Cutting edge: transcriptional profiling reveals multifunctional and cytotoxic antiviral responses of zika virus-specific CD8+ T cells
Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles
Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status
Differential recognition of mycobacterium tuberculosis-specific epitopes as a function of tuberculosis disease history
Durability of immune responses to the booster mRNA vaccination against COVID-19
Humoral and cellular immune memory to four COVID-19 vaccines
IEDB-3D 2.0: Structural data analysis within the Immune Epitope Database
The Cancer Epitope Database and Analysis Resource (CEDAR)
Impact of SARS-CoV-2 exposure history on the T cell and IgG response
Imprinting of gut-homing receptors on Mtb-specific Th1* cells is associated with reduced lung homing after gavage BCG vaccination of rhesus macaques
Circulating T cell-monocyte complexes are markers of immune perturbations
Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions
Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection
Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques
Virus-specific stem cell memory CD8+ T cells may indicate a long-term protection against evolving SARS-CoV-2
Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to Variants of Concern
The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic
IEDB and CEDAR: two sibling databases to serve the global scientific community
Targets and cross-reactivity of human T cell recognition of common cold coronaviruses
An update on studies characterizing adaptive immune responses in SARS-CoV-2 infection and COVID-19 vaccination
Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses
Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox
A systems vaccinology resource to develop and test computational models of immunity
Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
Monovalent SARS-CoV-2 mRNA vaccine does not boost Omicron-specific immune response in diabetic and control pediatric patients
Antigen discovery for next-generation pertussis vaccines using immunoproteomics and transposon directed insertion sequencing
Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination
Corrigendum: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
nteraction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination
Evaluation of cross-immunity to the Mpox virus due to historic Smallpox vaccination
T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer’s disease
Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
CD4+ T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword
An integrated workflow to assess technical and biological variability of cell population frequencies in human peripheral blood by flow cytometry
A prototype-pathogen approach for the development of Flavivirus countermeaseures
A measles virus-based vaccine induces robust chikungunya virus-specific CD4+ T-cell responses in a phase II clinical trial
The megapool approach to characterize adaptive CD4+ and CD8+ T cell responses
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children
Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
Early antiviral CD4 and CD8 T cell responses are associated with upper respiratory tract clearance of SARS-CoV-2
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
PINK1 is a target of T cell responses in Parkinson’s disease
T cell responses in pregnant women who received mRNA-based vaccination to prevent COVID-19 revealed unknown exposure to the natural infection and numerous SARS-CoV-2-specific CD4- CD8- double negative T cells and regulatory T cells
Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
Pre-existing SARS-2-specific T cells are predicted to cross-recognize BA.2.86
PEPMatch: a tool to identify short peptide sequence matches in large sets of proteins
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19
Thioamide analogues of MHC I antigen peptides
Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors
Mpox-specific immune responses elicited by vaccination or infection in people living with HIV
Safety and immunogenicity of booster vaccination and fractional dosing with Ad26.COV2.S or BNT162b2 in Ad26.COV2.S-vaccinated participants
A multi-omics systems vaccinology resource to develop and test computational models of immunity
Investigating viral and autoimmune T cell responses associated with post-acute sequelae of COVID-19
A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer
Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus
Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant
Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant
Combined antiviral therapy as effective and feasible option in allogenic hematopoietic stem cell transplantation during SARS-COV-2 infection: a case report
How COVID-19 ‘breakthrough’ infections alter your immune cells
LA JOLLA, CA—New research from scientists at La Jolla Institute for Immunology (LJI) suggests people who received COVID-19 vaccines and then experienced “breakthrough” infections are especially well armed against future SARS-CoV-2 infections.
LJI scientist Alison Tarke honored by Italian government
Tarke established important U.S.-Italy research collaborations amidst the COVID-19 pandemic
T cells tackle new ‘Pirola’ SARS-CoV-2 variant
LJI scientists harness bioinformatics to predict how T cells may adapt to fighting the highly mutated Pirola variant
Asymptomatic infections may underlie recent rise in whooping cough
Surprising insights on pertussis vaccines pave the way for next-gen protection
Family resemblance: How T cells could fight many coronaviruses at once
LJI researchers work to head off future pandemics by uncovering key similarities between SARS-CoV-2 and common cold coronaviruses
LJI Professor Alessandro Sette elected to the American Academy of Microbiology
Sette has led investigations into the T cell response to SARS-CoV-2, tuberculosis, and more
LJI scientists confirm smallpox vaccine also teaches T cells to fight mpox
There’s even more reason to think a vaccine developed against smallpox can help the body fight against mpox (monkeypox virus disease) as well, according to researchers at La Jolla Institute for Immunology (LJI).
LJI scientists reflect on what it means to make the “Highly Cited” list
A record number of LJI researchers have been named to the 2022 list, including two early career scientists
Your body remembers common cold coronaviruses from childhood. How can you get the same immunity to COVID-19?
COVID-19 boosters may lead to a stable antibody and T cell population in years to come
LJI scientists publish first head-to-head comparison of four COVID-19 vaccines
New investigation reveals the strength of T cell, B cell, and antibody responses over time
Scientists uncover new targets for treating Parkinson’s disease
LJI study suggests therapies could stop T cells from attacking brain cells in Parkinson's
Current vaccines teach T cells to fight Omicron
New LJI study shows how the fully vaccinated respond to a range of SARS-CoV-2 variants
¡Felicidades, Alba y Alex!
LJI COVID-19 researchers Alba Grifoni and Alessandro Sette win top honors from the Spanish Society of Immunology
T Cells Might Be Our Bodies’ Best Shot Against Omicron
When a T cell makes up its mind to kill, it does not mess around.
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
