Lab Sharma
Natalie Forster
Neha Reddy
Priyanka Saminathan
Sonia Sharma
Mousa Vatanmakanian
Mahati Rayadurgam
Maija Corey
Gwen Chan
Christine Oh
Claire Brancheau
Ahmad Alimadadi
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation
The TRAP1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1
cGAS-STING signaling regulates initial innate control of cytomegalovirus infection
Cytosolic sensing of immuno-stimulatory DNA, the enemy within
Binding of NUFIP2 to roquin promotes recognition and regulation of ICOS mRNA
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.
Functional analysis of immune signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production.
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.
Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome.
Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity.
Smooth-talking T cells leave asthma breathless.
Demographic and clinical characteristics associated with variations in antibody response to bnt162b2 covid-19 vaccination among healthcare workers at an academic medical centre: A longitudinal cohort analysis.
Human papillomavirus e5 suppresses immunity via inhibition of the immunoproteasome and sting pathway
Metabolic programs of T cell tissue residency empower tumour immunity
LJI scientists win ‘Prebys Research Heroes’ funding
Prebys Foundation celebrates ground-breaking female researchers
Sonia Sharma zeros in on metabolites
The mission is simple: Figure out which key molecules go missing in cancer patients.
Learning from men. Learning from women.
Men and women have different immune systems. With a better understanding of sex-specific immune differences, scientists can more effectively fight infections, cancers, heart disease, and even pregnancy complications.
Melanoma meets its match
How Ian Mathews used Tullie and Rickey Families SPARK Awards funding to make cancer therapy advances and launch a career in medicine
A clue to how some fast-growing tumors hide in plain sight
New LJI research could guide the development of more effective cancer immunotherapies
How to shift into COVID-19 research
Scientists who aren’t virologists or vaccinologists can still make crucial contributions to the global effort to battle SARS-CoV-2.
New Molecular Players in the cGAS-STING Pathway of Anti-Viral and Anti-Tumor Defense
Cell-free, immuno-stimulatory DNA is recognized in the cytoplasm of cells as a universal danger signal by the innate immune system. We are using genome-scale RNAi and CRISPR/Cas9 approaches in primary human cells to identify important new players in the cGAS-STING…
Targeting Tumor Endothelium for Cancer Surveillance and Immunotherapy
Preliminary data from our lab shows that vascular endothelial cells (vECs) mount remarkably potent innate responses to cell-free DNA, which is well in accordance with their role as sentinels of the blood. However, little is known about how the contribution…
Molecular Mechanisms Underlying Novel Interferonopathies
In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are associated with the development of auto-immune diseases in humans. We have used a forward genetic approach to identify novel negative…
Researchers track down metabolic enzyme that protects against inflammation
LJI study shows new link between metabolism and the immune system
