New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
LJI scientists zero in on T cells that may drive autoimmune disease in human patients
Lab Vijayanand
Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease
Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients
Sputum IL-6 concentrations in severe asthma and its relationship with FEV1
Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V.
An integrated nano-scale approach to profile miRNAs in limited clinical samples
Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data
Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features
Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with allergen-specific modulation of immune reactivity
Identification of a novel cis-regulatory element essential for immune tolerance
Control of Foxp3 stability through modulation of TET activity.
Unique phenotypes and clonal expansions of human CD4 effector memory T cell re-expressing CD45RA
Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.
Transcriptomic analysis of CD4+ T cells reveals novel immune signatures of latent tuberculosis
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma
Evaluating the effect of immune cells on the outcome of patients with mesothelioma
Head and neck squamous cell carcinomas are characterized by a stable immune signature within the primary tumor over time and space
Targeting the myofibroblastic cancer-associated fibroblast phenotype through inhibition of NOX4
An integrated and semiautomated microscaled approach to profile cis-regulatory elements by histone modification ChIP-Seq for large-scale epigenetic studies
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
Identification of significant chromatin contacts from HiChIP data by FitHiChIP
Publisher Correction: Innate-like functions of natural killer T cell subsets result from highly divergent gene programs
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Constitutive Activation of Natural Killer Cells in Primary Biliary Cholangitis.
Single-cell analysis to understand the diversity of immune cell types that drive disease pathogenesis.
Molecular signatures of Dengue virus-specific IL-10/FN-g co-producing CD4 T clls and their association with Dengue disease
Primary prevention of asthma in high-risk children using HDM SLIT: Assessment at age 6 years.
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Quantitative and Qualitative Perturbations of CD8 + MAITs in Healthy Mycobacterium tuberculosis-Infected Individuals
CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage.
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants.
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells.
PrecISE: precision medicine in severe asthma: An adaptive platform trial with biomarker ascertainment.
Multi-cell type gene coexpression network analysis reveals coordinated interferon response and cross-cell type correlations in systemic lupus erythematosus.
Functional analysis of immune signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production.
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy.
HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients.
The clinical implications of aspergillus fumigatus sensitization in difficult-to-treat asthma patients.
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis
CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature.
Thymus-derived CD4+CD8+ cells reside in mediastinal adipose tissue and the aortic arch.
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants
JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells.
Cutting edge: transcriptional profiling reveals multifunctional and cytotoxic antiviral responses of zika virus-specific CD8+ T cells
Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles
Differential recognition of mycobacterium tuberculosis-specific epitopes as a function of tuberculosis disease history
Human eosinophils express a distinct gene expression program in response to IL-3 compared with common β-chain cytokines IL-5 and GM-CSF
Identification of an early unipotent neutrophil progenitor with pro-tumoral activity in mouse and human bone marrow
Impact of genetic polymorphisms on human immune cell gene expression
Innate-like functions of natural killer T cell subsets result from highly divergent programs
Circulating T cell-monocyte complexes are markers of immune perturbations
Divergent metabolic programmes control two populations of mait cells that protect the lung
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
Comprehensive Characterization of Difficult-to-Treat Asthma Reveals Near Absence of T2-Low Status.
An integrated workflow to assess technical and biological variability of cell population frequencies in human peripheral blood by flow cytometry
Cytotoxic CD4+ tissue-resident memory T cells are associated with asthma severity.
A sensitive and integrated approach to profile messenger RNA from samples with low cell numbers
Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.
Researchers discover potentially cancer-fighting T cells within some pediatric brain tumor patients
New research suggests a small group of pediatric brain tumor patients may benefit from immunotherapy
Asthma researcher Sara Herrera de la Mata wins BioLegend Graduate Fellowship in Immunology
Herrera de la Mata aims to understand how asthma turns deadly
Investigating cancer drug toxicity leads to a critical discovery
Researchers uncover a new strategy to avoid cancer immunotherapy side effects
LJI team uncovers new subsets of CD4+ ‘helper’ T cells
New analysis shows men and women really do have immune cell differences
COVID-19 case severity: How genetic differences leave immune cells at a disadvantage
New LJI research shows how a range of critical immune cells respond to SARS-CoV-2
Many cancer patients may need a sequential one-two punch of immunotherapies
Treating patients with anti-CTLA4 therapies prior to anti-PD1 treatment may be a promising strategy
A new window into autoimmune diseases
LJI scientists uncover coordinated immune cell activity as a driver of systemic lupus erythematosus
Genetic basis of immune-mediated diseases
While an enormous number of genetic variants have been associated with risk for human disease, how these variants affect gene expression in various cell types remains largely unknown. To address this gap as it relates to immune cells, as…
Role of T cell in allergy and Asthma
Selected References Grégory Seumois, Ciro Ramírez-Suástegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters, Alessandro Sette, Vijayanand P (2020). Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma. Science Immunology. 2020 Jun 12;5(48):eaba6087. doi: 10.1126 PMID: 32532832. PMCID:…
Role of T Cells in Viral Infections (Including SARS-CoV-2)
Selected References Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+T cells. Sci Immunol. 2021…
Cancer Immunology
In 2013, Dr. Vijayanand teamed up with Professor Christian Ottensmeier at the Cancer Center, University of Southampton, UK, to set up a large patient-centered cancer immunology program. Our work utilizing genomics tools to study T lymphocytes present in cancer…
LJI asthma researcher Jermaine Khumalo receives AAI Intersect Fellowship
New fellowship will support data science and immunology cross-training in two pioneering LJI labs
A closer look at T cells reveals big differences in mild vs. severe COVID-19 cases
New research highlights the enormous variability in how T cells respond to the deadly virus
New 3D maps reveal inner workings of immune cell gene expression
LJI scientists track down control elements that govern gene expression from a distance
COVID-19 and T cells: Single-cell transcriptomic analysis of SARS-CoV-2-reactive CD8 + and CD4 + T cells.
As the SARS-CoV-2 related disease COVID-19 hit hard and changed the lives of every person on earth, the Vijayanand lab recently started to put their expertise in single-cell analysis of T cells responding to SARS-CoV-2 and other respiratory viruses.…
Epigenetics
The Vijayanand lab has a strong interest in understanding the role of T cell enhancers (epigenetics players) in asthma, developing cutting-edge tools to study enhancer function, and utilizing these tools to understand the molecular basis of asthma. This includes…
Every COVID-19 case seems different. These scientists want to know why.
Scientists in the U.S. and U.K. publish first in-depth look at how CD4+ T cells fight SARS-CoV-2
T cell biology and Asthma
The Vijayanand lab employs genomic and epigenomic tools to understand the molecular basis of asthma, making key contributions in understanding the immunological basis of asthma, including identifying CCR4 as a key chemokine receptor that regulates recruitment of T cells…
Genetics of Human Diseases
While an enormous number of genetic variants have been associated with risk for human disease, how these variants affect gene expression in various cell types remains largely unknown. To address this gap as it relates to immune cells, as…
Cancer Immunology
In 2013, Dr. Vijayanand teamed up with Professor Christian Ottensmeier at the Cancer Center, University of Southampton, UK, to set up a large patient-centered cancer immunology program utilizing genomics tools to study T lymphocytes present in cancer tissue which…
LJI scientists uncover immune cells that may lower airway allergy and asthma risk
Study opens up new path to research to fighting allergic diseases
To kill tumors, activate this elite group of T cells
LJI’s new understanding of killer T cells inspires clinical studies of potential immunotherapies
