LJI team uncovers new subsets of CD4+ ‘helper’ T cells
New analysis shows men and women really do have immune cell differences
Lab Vijayanand
COVID-19 case severity: How genetic differences leave immune cells at a disadvantage
New LJI research shows how a range of critical immune cells respond to SARS-CoV-2
Many cancer patients may need a sequential one-two punch of immunotherapies
Treating patients with anti-CTLA4 therapies prior to anti-PD1 treatment may be a promising strategy
A new window into autoimmune diseases
LJI scientists uncover coordinated immune cell activity as a driver of systemic lupus erythematosus
Genetic basis of immune-mediated diseases
While an enormous number of genetic variants have been associated with risk for human disease, how these variants affect gene expression in various cell types remains largely unknown. To address this gap as it relates to immune cells, as…
Role of T cell in allergy and Asthma
Selected References Grégory Seumois, Ciro Ramírez-Suástegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters, Alessandro Sette, Vijayanand P (2020). Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma. Science Immunology. 2020 Jun 12;5(48):eaba6087. doi: 10.1126 PMID: 32532832. PMCID:…
Role of T Cells in Viral Infections (Including SARS-CoV-2)
Selected References Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+T cells. Sci Immunol. 2021…
Cancer Immunology
In 2013, Dr. Vijayanand teamed up with Professor Christian Ottensmeier at the Cancer Center, University of Southampton, UK, to set up a large patient-centered cancer immunology program. Our work utilizing genomics tools to study T lymphocytes present in cancer…
LJI asthma researcher Jermaine Khumalo receives AAI Intersect Fellowship
New fellowship will support data science and immunology cross-training in two pioneering LJI labs
A closer look at T cells reveals big differences in mild vs. severe COVID-19 cases
New research highlights the enormous variability in how T cells respond to the deadly virus
New 3D maps reveal inner workings of immune cell gene expression
LJI scientists track down control elements that govern gene expression from a distance
Epigenetics
The Vijayanand lab has a strong interest in understanding the role of T cell enhancers (epigenetics players) in asthma, developing cutting-edge tools to study enhancer function, and utilizing these tools to understand the molecular basis of asthma. This includes…
COVID-19 and T cells: Single-cell transcriptomic analysis of SARS-CoV-2-reactive CD8 + and CD4 + T cells.
As the SARS-CoV-2 related disease COVID-19 hit hard and changed the lives of every person on earth, the Vijayanand lab recently started to put their expertise in single-cell analysis of T cells responding to SARS-CoV-2 and other respiratory viruses.…
Every COVID-19 case seems different. These scientists want to know why.
Scientists in the U.S. and U.K. publish first in-depth look at how CD4+ T cells fight SARS-CoV-2
T cell biology and Asthma
The Vijayanand lab employs genomic and epigenomic tools to understand the molecular basis of asthma, making key contributions in understanding the immunological basis of asthma, including identifying CCR4 as a key chemokine receptor that regulates recruitment of T cells…
Genetics of Human Diseases
While an enormous number of genetic variants have been associated with risk for human disease, how these variants affect gene expression in various cell types remains largely unknown. To address this gap as it relates to immune cells, as…
Cancer Immunology
In 2013, Dr. Vijayanand teamed up with Professor Christian Ottensmeier at the Cancer Center, University of Southampton, UK, to set up a large patient-centered cancer immunology program utilizing genomics tools to study T lymphocytes present in cancer tissue which…
LJI scientists uncover immune cells that may lower airway allergy and asthma risk
Study opens up new path to research to fighting allergic diseases
To kill tumors, activate this elite group of T cells
LJI’s new understanding of killer T cells inspires clinical studies of potential immunotherapies
