Lab Von Herrath
Alpha cells, the main source of IL-1β in human pancreas
Antigen-specific peptide immunotherapy for type 1 diabetes: proof of safety, hope for efficacy
β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?
Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes
The shifting paradigm of a “cure” for type 1 diabetes: is technology replacing immune based therapies?
Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post ranslational modifications
α cell function and gene expression are compromised in type 1 diabetes
Suppression of diabetes by accumulation of non-islet-specific CD8+ effector T cells in pancreatic islets
OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration
Distinct housing conditions reveal a major impact of adaptive immunity on the course of obesity-induced type 2 diabetes
Loss of IDO1 expression from human pancreatic β-Cells precedes their destruction during the development of Type 1 Diabetes
Regulatory immune mechanisms beyond regulatory T cells
Long-term viability through selective permeability
The Urgent Need for Integrated Science to Fight COVID-19 Pandemic and Beyond
New insights into the role of autoreactive CD8 T cells and cytokines in human type 1 diabetes.
The effect of Toll-like receptor stimulation on the motility of regulatory T cells.
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
Corona Pandemic: Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society
HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes.
Current and future therapies for type 1 diabetes.
One in ten CD8 + cells in the pancreas of living individuals with recent-onset type 1 diabetes recognizes the preproinsulin epitope PPI 15-24.
Means, motive, and opportunity: do non-islet-reactive infiltrating T cells contribute to autoimmunity in type 1 diabetes?
Current state of antigen-specific immunotherapy for type 1 diabetes.
Peripheral autoreactive CD8 T-cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes.
IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.
Multicomponent plasmid protects mice from spontaneous autoimmune diabetes.
How benign autoimmunity becomes detrimental in type 1 diabetes.
Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes
Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives
Effect of IL4 and IL10 on a human in vitro type 1 diabetes model
Induction of antigenic immune tolerance to delay type 1 diabetes – challenges for clinical translation
Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes
Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice
IL-4R is expressed on alpha and beta cells of human pancreata.
Unmasking the pancreas
No one knows exactly what triggers type 1 diabetes, but researchers at La Jolla Institute for Immunology have uncovered some fascinating clues.
LJI research leads to promising combination therapy for type 1 diabetes
Phase 2 trial run by Novo Nordisk emphasizes the importance of translational research
Diabetes researchers spot dangerous T cells in the pancreas—even in healthy people
LA JOLLA—Your pancreas is studded with cell clusters called islets. In most people, special beta cells live snug in the islets, happily making the insulin that the body uses to regulate blood sugar. But in people with type 1 diabetes,…
Blocking nerve signals to the pancreas halts type 1 diabetes onset in mice
New LJI discovery could help explain patterns of cell death in many autoimmune diseases
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes
Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies capable of preventing or permanently reversing the disease. Due to the inaccessibility of human pancreatic tissue, our knowledge of the…
Neuro-immune crosstalk in the pancreas during onset of type 1 diabetes
Team: Gustaf Christoffersson The histopathologic features of human type 1 diabetes are remarkably heterogeneous throughout the pancreas. One lobule of the organ can appear completely unaffected by the ongoing autoimmune disease, while the neighboring lobule lacks any sign of an…
