There are many ways to make the world a better place. “It seemed to me that Medicine tackled problems “one patient at a time,” while science promised to be able to get to the root of a problem to solve it once and for all,” Dr. Alessandro Sette recounted in a recent profile that traces the arc of his career, from student at the Liceo Classico Torquato Tasso in Rome, Italy, to Head of the Division of Vaccine Discovery at LJI. Regardless of whether he studies an infection like TB or severe reactions to seasonal allergens, his work is always based on the same fundamental question: What makes a good immune response? And how can we design immune treatments to mimic it? For the full profile, visit “Portrait of an optimist.”