Projects
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4 T cells and directed towards dietary gluten. CD is the [...]
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium of the small intestine in humans and mice. intraepithelial T [...]
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance for T cells is initially established during thymic selection and [...]
MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system can take to prepare the host to deal with challenges [...]
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role in controlling autoimmune diseases, graft rejections and tumor rejection. We [...]
