Over the last 15 years our lab has been studying the link between lymphotoxins (LT) and the regulation of type I interferons (IFN-I) during CMV infection. Mice deficient in LT

Virulent isolates of CMV encode the ul144 orf, and we identified UL144 as an orthologue of the herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily. When the

HCMV-specific CD8 T cells protect bone marrow transplant patients when used in cellular immunotherapy, and their long-term maintenance is enhanced by CD4 T cells. Importantly, a robust HCMV-specific CD4 T

We have recently discovered a novel connection between the TNF-related apoptosis inducing ligand (TRAIL) cytokine system and CMV. TRAIL is a TNF-family cytokine that can bind to several receptors (TRAIL