How can we enhance tissue immunity?
As the mechanistic principles guiding tissue immunity unfold, the Reina Laboratory will focus on leveraging immune engineering technologies to enhance
How is the tissue context enabling TRM-driven immunity?
Spatial transcriptomics at single-molecule resolution allows in situ measurements of hundreds to thousands of genes in large areas of tissues,
What are the tissue-specific intrinsic adaptations of TRM?
Long-term tissue residency is a complex, context-dependent challenge requiring specific cellular adaptation strategies. Our recent work has identified common metabolic
Neurodegenerative Diseases
The aim of this work funded by Aligning Science Across Parkinson’s (ASAP), in collaboration with Dr. Alessandro Sette, is to
Tuberculosis
The aim of this work, in collaboration with Dr. Bjoern Peters, is to identify and characterize T cell epitopes from
Cancer Immunology
In 2013, Dr. Vijayanand teamed up with Professor Christian Ottensmeier at the Cancer Center, University of Southampton, UK, to
Role of T Cells in Viral Infections (Including SARS-CoV-2)
Selected References Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay
Role of T cell in allergy and Asthma
Selected References Grégory Seumois, Ciro Ramírez-Suástegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters, Alessandro Sette, Vijayanand P (2020). Single-cell
Genetic basis of immune-mediated diseases
While an enormous number of genetic variants have been associated with risk for human disease, how these variants affect
Athlerosclerosis
ATHEROSCLEROSIS Working in collaboration with LJI Professor Klaus Ley, the Sette Lab aims to help develop vaccines that target inflammatory
Neuro-immune crosstalk in the pancreas during onset of type 1 diabetes
Team: Gustaf Christoffersson The histopathologic features of human type 1 diabetes are remarkably heterogeneous throughout the pancreas. One lobule of
Modeling and detection of viral infections in human pancreas slices
Team: Mehdi Benkahla It is thought that an interaction between predisposing genes and environmental factors, such as viral infections, may