Allergy
Cockroach Allergy: The Sette lab is working to identify the sites on allergen molecules that trigger an inflammatory immune response.
Dengue Virus
The Sette lab’s previous large scale epitope identification efforts (supported by HHS contracts) have led to a deeper understanding of
Tuberculosis
T cell responses to Mycobacterium tuberculosis infection and vaccination: Following completion of a massive epitope discovery effort (also supported by
SARS-COV-2
Reactivity study: A collaboration between the Sette lab and Shane Crotty, Ph.D., to document acquired immunity to SARS-CoV-2 and help
Cancer
Immunotherapies for head and neck cancer: To develop new cancer therapies by studying how the immune system, by way of
SARS-COV-2
COVIC-DB: To co-run the LJI-led CoVIC database in the effort to find ideal therapeutic combinations for the novel coronavirus, the
Data Standards
HIPC Data Standards: A collaboration with various centers of the Human Immune Profiling Consortium (HIPC) to build upon the existing
Epigenetic and Transcriptomic Profile of Human Immune Cells
The lab aims to perform epigenetic and transcriptomic analyses of purified circulating immune cell types from healthy human subjects. NIH/NIAID
Allergic Diseases
Pediatric Milk Allergy: To study the frequency and phenotype of milk allergen-specific T cells in cohorts with different disease manifestations
Whooping Cough
Research to identify mechanisms and correlates of long-lasting vaccine-induced immunity to whooping cough. The lab aims to define transcriptional responses
Tuberculosis
Investigation of human immune signatures of latent MTB infection, active disease and BCG vaccination. (NIH/NIAID, U19 AI118626) Proteome-wide characterization of
Immune Epitope Database and Analysis Resource Program
A collaboration with LJI Professor Alessandro Sette, Dr. Biol. Sci, to maintain and further develop the Immune Epitope Database (IEDB) and associated