Atherosclerosis Vaccine
Neutrophil Adhesion and Activation
Mucosal Immunology and IBD
A major area of research in our laboratory is the regulation of mucosal immunity. We have collaborated extensively with the
NKT Cell Immunology
Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these
IgE Heterogeneity
Since their finding of ‘monomeric IgE effects’ on mast cell survival in 2001, Dr. Kawakami and associates have shown that
Phospholipase C (PLC)-B3-Mediated Regulation of Stat5 Activity
Given their previous studies on crosstalks between PTKs-dependent and G protein-coupled receptor-dependent signals in FceRI-stimulated mast cells, they have been
Mouse Model of Atopic Dermatitis (AD)
As our knowledge of the FceRI-mediated signal transduction has grown for the last two decades, the need to study in
Btk-Mediated Regulation of Cytokine Production
During the course of the above-mentioned study, they found interactions between Btk and protein kinase C (PKC)-b and terreic acid
Bruton’s Tyrosine Kinase (Btk) in Mast Cell Activation
Dr. Kawakami has been using the high-affinity IgE receptor (FceRI) signaling in mast cells as a model system. Following his