Publications New

May 1, 2022 Nat Cardiovasc Res

Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease

Saigusa R, Roy P, Freuchet A, Gulati R, Ghosheh Y, Suthahar SSA, Durant CP, Hanna DB, Kiosses WB, Orecchioni M, Wen L, Wu R, Kuniholm MH, Landay AL, Anastos K, Tien PC, Gange SJ, Kassaye S, Vallejo J, Hedrick CC, Kwok WW, Sette A, Hodis HN, Kaplan RC, Ley K.

May 1, 2022 Nature

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.

Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH.

May 1, 2022 Nature

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

Simon Eschweiler, Ciro Ramírez-Suástegui, Yingcong Li, Emma King, Lindsey Chudley, Jaya Thomas, Oliver Wood, Adrian von Witzleben, anielle Jeffrey, Katy McCann, Hayley Simon, Monalisa Mondal, Alice Wang, Martina Dicker, Elena Lopez-Guadamillas, Ting-Fang Chou, Nicola A Dobbs, Louisa Essame, Gary Acton, Fiona Kelly, Gavin Halbert, Joseph J Sacco, Andrew Graeme Schache, Richard Shaw, James Anthony McCaul, Claire Paterson, Joseph H Davies, Peter A Brennan, Rabindra P Singh, Paul M Loadman, William Wilson, Allan Hackshaw, Gregory Seumois, Klaus Okkenhaug, Gareth J Thomas, Terry M Jones, Ferhat Ay, Greg Friberg, Mitchell Kronenberg, Bart Vanhaesebroeck, Pandurangan Vijayanan, Christian H Ottensmeier

Apr 28, 2022 Clin Transl Gastroeterol

Preserved SARS-CoV-2 vaccine cell-mediated immunogenicity in inflammatory bowel disease patients on immune-modulating therapies

Boland BS, Goodwin B, Zhang Z, Bloom N, Kato Y, Neill J, Le H, Tysl T, Collins AE, Dulai PS, Singh S, Nguyen NH, Grifoni A, Sette A, Weiskopf D, Chang JT, Dan JM

Apr 14, 2022 Vaccines (Basel)

Transcriptomics of acute DENV-specific CD8+ T cells does not support qualitative differences as drivers of disease severity

Grifoni A, Voic H, Yu ED, Mateus J, Yan Fung KM, Wang A, Seumois G, De Silva AD, Tennekon R, Premawansa S, Premawansa G, Tippalagama R, Wijewickrama A, Chawla A, Greenbaum J, Peters B, Pandurangan V, Weiskopf D, Sette A

Apr 14, 2022 Front Immunol

CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer

Olingy C, Alimadadi A, Araujo DJ, Barry D, Gutierrez NA, Werbin MH, Arriola E, Patel SP, Ottensmeier CH, Dinh HQ, Hedrick CC.

Apr 12, 2022 Cell Rep

A zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity.

Regla-Nava JA, Wang YT, Fontes-Garfias CR, Liu Y, Syed T, Susantono M, Gonzalez A, Viramontes KM, Verma SK, Kim K, Landeras-Bueno S, Huang CT, Prigozhin DM, Gleeson JG, Terskikh AV, Shi PY, Shresta S.

Apr 4, 2022 Nature

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.

Apr 1, 2022 Nat Rev Immunol

How the immune system shapes atherosclerosis: Roles of innate and adaptive immunity.

Roy P, Orecchioni M, Ley K.

Apr 1, 2022 J Biol Chem

Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli

Kushnareva Y, Moraes V, Suess J, Peters B, Newmeyer DD, Kuwana T

Apr 1, 2022 JAMA Neurol

Responses after a third dose of mRNA COVID-19 vaccine among patients with multiple sclerosis treated with Ocrelizumab

Madelon N, Heikkilä N, Sabater Royo I, Fontannaz P, Breville G, Lauper K, Goldstein R, Grifoni A, Sette A, Siegrist CA, Finckh A, Lalive PH, Didierlaurent AM, Eberhardt CS

Apr 1, 2022 Lancet Microbe

Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial

Chiuppesi F, Zaia JA, Frankel PH, Stan R, Drake J, Williams B, Acosta AM, Francis K, Taplitz RA, Dickter JK, Dadwal S, Puing AG, Nanayakkara DD, Ash P, Cui Y, Contreras H, La Rosa C, Tiemann K, Park Y, Medina J, Iniguez A, Zhou Q, Karpinski V, Johnson D, Faircloth K, Kaltcheva T, Nguyen J, Kha M, Nguyen VH, Francisco SO, Grifoni A, Wong A, Sette A, Wussow F, Diamond DJ