Role of T Cells in Viral Infections (Including SARS-CoV-2)

 

Selected References

1. Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8⁺T cells. Sci Immunol. 2021 Jan 21;6(55):eabe4782. doi: 10.1126/sciimmunol.abe4782. PMID: 33478949.
2. Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4⁺T Cells in COVID-19. Cell. 2020 Nov 25;183(5):1340-1353.e16. doi: 10.1016/j.cell.2020.10.001. Epub 2020 Oct 5. PMID: 33096020; PMCID: PMC7534589.
3. Patil VS, Madrigal A, Schmiedel BJ, Clarke J, O’Rourke P, de Silva AD, Harris E, Peters B, Seumois G, Weiskopf D, Sette A, Vijayanand P. Precursors of human CD4⁺cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Sci Immunol. 2018 Jan 19;3(19):eaan8664. doi: 10.1126/sciimmunol.aan8664. PMID: 29352091; PMCID: PMC5931334.

 

Grants

NIH/NCI U01 CA260588-01, SARS-CoV-2-reactive tissue-resident memory T cells in healthy and cancer subjects

NIH/NIAID, U19AI14273-S1, Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses

NIH/NIAID, U19AI142742-03, Cooperative Centers on Human Immunology: Biology of human cytotoxic cd4 t cells (CD4-CTLs) in viral infections