Publications

The variety of study in the field of emerging viruses.

Saphire EO, Feldmann H.

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.

Hastie KM, Bale S, Kimberlin CR, Saphire EO.

The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.

Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO.

Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus.

Olal D, Kuehne AI, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM Jr, Saphire EO.

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion.

Bale S, Liu T, Li S, Wang Y, Abelson D, Fusco M, Woods VL Jr, Saphire EO.

A shared structural solution for neutralizing ebolaviruses.

Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO.

Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.

Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL Jr, de la Torre JC, Saphire EO.

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change.

Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM.

Measles virus fusion shifts into gear.

Saphire EO, Oldstone MB.

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression.

Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO.

Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.

Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, MacRae IJ, Saphire EO.

Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.

Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO.