Publications

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it.

Lee JE, Saphire EO.

An efficient platform for screening expression and crystallization of glycoproteins produced in human cells.

Lee JE, Fusco ML, Saphire EO.

Ebolavirus glycoprotein structure and mechanism of entry.

Lee JE, Saphire EO.

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.

Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO.

Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.

Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EO.

Structure of a high-affinity “mimotope” peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.

Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA.

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.

Cárdenas WB, Loo YM, Gale M Jr, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.

Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM.

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.

Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA.

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop.

Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA.

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

Pantophlet R, Ollmann Saphire E, Poignard P, Parren PW, Wilson IA, Burton DR.

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1–>2 mannose residues on the outer face of gp120.

Scanlan CN, Pantophlet R, Wormald MR, Ollmann Saphire E, Stanfield R, Wilson IA, Katinger H, Dwek RA, Rudd PM, Burton DR.