Publications

Oct 22, 2021 Science.

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: a global consortium study.

Hastie KM, Li H, Bedinger D, Schendel SL, Dennison SM, Li K, Rayaprolu V, Yu X, Mann C, Zandonatti M, Avalos Diaz R, Zyla D, Buck T, Hui S, Shaffer K, Hariharan C, Yin J, Olmedillas E, Enrqiuez A, Parekh D, Abraha M, Feeney E, Horn GQ, CoVIC-DB team1, Aldon Y, Ali H, Aracic S, Cobb RR, Federman RS, Fernandez JM, Glanville J, Green R, Grigoryan G, Lujan Hernandez AG, Ho DD, Huang KA, Ingraham J, Jiang W, Kellam P, Kim C, Kim M, Kim HM, Kong C, Krebs SJ, Lan F, Lang G, Lee S, Leung CL, Liu J, Lu Y, MacCamy A, McGuire AT, Palser AL, Rabitts TH, Tehrani ZR, Sajadi MM, Sanders RW, Sato AK, Schweizer L, Seo J, Shen B, Snitselaar JJ, Stamatatos L, Tan Y, Tomic MT, van Gils M, Youssef S, Yu J, Yuan TZ, Zhang Q, Peters B, Tomaras GD, Germann T, Saphire EO.

Sep 21, 2021 Cell Rep Med.

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.

Gorman MJ, Patel N, Guebre-Xabier M, Zhu AL, Atyeo C, Pullen KM, Loos C, Goez-Gazi Y, Carrion Jr R, Jing-Tian H, Yuan D, Bowman KA, Zhou B, Maciejewski S, McGrath ME, Logue JL, Frieman MB, Montefiori D, Mann C, Schendel S, Amanat F, Krammer F, Saphire EO, Lauffenburger DA, Greene AM, Portnoff AD, Massare MJ, Ellingsworth L, Glenn G, Smith G, Alter G.

Jul 27, 2021 Cell Rep.

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.

Hassan AO, Shrihari S, Gorman MJ, Ying B, Yaun D, Raju S, Chen RE, Dmitriev IP, Kashentseva E, Adams LJ, Mann C, Davis-Gardner ME, Suthar MS, Shi PY, Saphire EO, Fremont DH, Curiel DT, Alter G, Diamond MS.

Jul 16, 2021 Front Immunol.

Proteo-genomic analysis identifies two major sites of vulnerability on ebolavirus glycoprotein for neutralizing antibodies in convalescent human plasma.

Gilchuk P, Guthals A, Bonissone SR, Shaw JB, Ilinykh PA, Huang K, Bombardi RG, Liang J, Grinyo A, Davidson E, Chen EC, Gunn BM, Alter G, Saphire EO, Doranz BJ, Bukreyev A, Zeitlin L, Castellana N, Crowe JE Jr.

Jul 14, 2021 Sci Transl Med.

Ebola vaccine-induced protection in non-human primates correlates with antibody specificity and Fc-mediated effects.

Meyer M, Gunn BM, Malherbe DC, Gangavarapu K, Yoshida A, Pietzsch C, Kuzmina NA, Saphire EO, Collins PL, Crowe JE Jr, Zhu JJ, Suchard MA, Brining DL, Mire CE, Cross RW, Geisbert JB, Samal SK, Andersen KG, Alter G, Geisbert TW, Bukreyev A.

Apr 13, 2021 Cell Rep.

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form.

Landeras-Bueno S, Wasserman H, Oliveira G, VanAernum Z, Busch F, Salie ZL, Wysocki VH, Andersen K, Saphire EO.

Apr 13, 2021 Immunity.

A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus.

Gunn BM, Lu R, Slein MD, Ilinykh PA, Huang K, Atyeao C, Shcendel SL, Kim J, Cain C, Roy V, Suscovich TJ, Takada A, Halfmann PJ, Kawaoka Y, Pauthner MG, Momoh M, Goba A, Kanneh L, Andersen KG, Schieffelin JS, Grant D, Garry RF, Saphire EO, Bukreyev A, Alter G.

Feb 5, 2021 Science.

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.

Feb 4, 2021 PLoS Pathog.

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry.

Schafer A, Xiong R, Cooper L, Nowar R, Lee H, Li Y, Ramirez BE, Peet NP, Caffrey M, Thatcher GRJ, Saphire EO, Cheng H, Rong L.

Feb 3, 2021 J Virol.

Prominent neutralizing antibody response targeting the ebolavirus glycoprotein subunit interface elicited by immunization.

Wang Y, Howell KA, Brannan J, Aganas KN, Turner HL, Wirchnianski AS, Kailasan S, Fusco M, Galkin A, Chiang C, Zhao X, Saphire EO, Chandran K, Ward AB, Dye JM, Aman MJ, Geisbert TW, Li Y.

Jan 1, 2021 Methods Mol Biol.

Analysis of oligomeric and glycosylated proteins by size-exclusion chromatography coupled with multiangle light scattering.

Hastie KM, Rayaprolu V, Saphire EO.

Jan 1, 2021 Nat Struct Mol Biol.

Structural biology in the fight against COVID-19.

Barcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q.