Publications

Feb 1, 2021 J Exp Med.

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.

Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G, Vijayanand P, Schief WR, Crotty S.

Jan 15, 2021 EMBO J.

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.

Wang X, Ray R, Kratochvil S, Melzi E, Lin YC, Giguere S, Xu L, Warner J, Cheon D, Liguori A, Groschel B, Phelps N, Adachi Y, Tingle R, Wu L, Crotty S, Kirsch KH, Nair U, Schief WR, Batista FD.

Jan 1, 2021 Semin Immunol.

HIV vaccinology: 2021 update.

Lee JH, Crotty S.

Oct 6, 2020 Nat Rev Immunol

Cross-reactive memory T cells and herd immunity to SARS-CoV-2

Lipsitch M, Grad YH, Sette A, Crotty S

Sep 16, 2020 Cell

Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

Rydyznski Moderbacher C, Ramirez SI, Dan JM, Grifoni A, Hastie KM, Weiskopf D, Belanger S, Abbott RK, Kim C, Choi J, Kato Y, Crotty EG, Kim C, Rawlings SA, Mateus J, Tse LPV, Frazier A, Baric R, Peters B, Greenbaum J, Ollmann Saphire E, Smith DM, Sette A, Crotty S

Sep 15, 2020 PNAS

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

Huang D, Abbott RK, Havenar-Daughton C, Skog PD, Al-Kolla R, Groschel B, Blane TR, Menis S, Tran JT, Thinnes TC, Volpi SA, Pintea M, Voss JE, Philps N, Tingle R, Rodriguez AR, Martin G, Kupryianov S, Schief WR, Nemazee D, Crotty S

Sep 15, 2020 Immunity

Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo

Kato Y, Abbott RK, Freeman BL, Haupt S, Groschel B, Silva M, Menis S, Irvine DJ, Schief WR, Crotty S

Aug 5, 2020 NPJ Vaccines

Targeting HIV Env immunogens to B cell follicles in nonhuman primate through immune complex or protein nanoparticle formulations

Martin JT, Cottrel CAl, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ

Aug 4, 2020 Science

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D.

Jul 7, 2020 Nat Rev Immunol

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Sette, A., Crotty, S

May 20, 2020 Cell

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

Grifoni, A., Weiskopf, D., Ramirez, S.I., Mateus, J., Dan, J.M., Moderbacher, C.R., Rawlings, S.A., Sutherland, A., Premkumar, L., Jadi, R.S., Marrama, D., de Silva, A.M., Frazier, A., Carlin, A., Greenbaum, J.A., Peters, B., Krammer, F., Smith, D.M., Crotty, S., Sette, A.,

Apr 1, 2020 J Immunol Methods

Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

Havenar-Daughton C, Newton IG, Somaya SY, Reiss SM, Schwan B, Suh MJ, Hastech F, Levi G, Crotty S