Publications

Jul 4, 2018 Sci Transl Med

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

Havenar-Daughton C, Sarkar A, Kulp DW, Toy L, Hu X, Deresa I, Kalyuzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, Reiss SM, Seumois G, Yates JR, Paulson JC, Bosinger SE, Wilson IA, Schief WR, Crotty S

May 1, 2018 Virology

Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets

Meng X, Kaever T, Yan B, Trktman P, Zajonc DM, Peters B, Crotty S, Xiang Y

Apr 17, 2018 Immunity

The transcription factor Runx3 establishes chromatin accessibility of cis-regulatory landscapes that drive memory cytotoxic T lymphocyte formation

Wang D, Diao H, Getzler AJ, Rogal W, Frederick MA, Milner J, Yu B, Crotty S, Goldrath AW, Pipkin ME

Mar 20, 2018 Genome Med

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

Upadhyay AA, Kauffman RC, Wolabaugh AN, Cho A, Patel NB, Reiss SM, Havenar-Daughton C, Dawoud RA, Tharp GK, Sanz L, Pulendran B, Crotty S, Lee FE, Wrammert J, Bosinger SE

Mar 15, 2018 Nat Commun

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis

Dalia Gaddis D, Lindsey Padgett L, Runpei Wu R, Chantel McSkimming C, Romines V, Taylor A, McNamara C, Kronenberg M, Crotty S, Thomas M, Sorci-Thomas M, Hedrick C

Mar 1, 2018 Cold Spring Harb Perspect Biol

Do memory CD4 T cells keep their cell-type programming: plasticity versus fate commitment? Complexities of interpretation due to the heterogeneity of memory CD4 T cells including T follicular helper cells

Crotty S

Feb 23, 2018 PLoS Pathog

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP

Feb 1, 2018 Nat Rev Immunol

Raging evolution of a B cell response to a viral infection

Crotty S

Feb 1, 2018 J Allergy Clin Immunol

Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells

Schulten V, Tripple V, Seumois G, Qian Y, Scheuemann RH, Fu Z, Locci M, Rosales S, Vijayanand P, Sette A, Alam R, Crotty S, Peters B

Jan 16, 2018 Immunity

Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens

Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S

Jan 5, 2018 J Biol Chem

Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Brita A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM

Dec 14, 2017 Nature

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW