Research Center Center for Sex-based Differences in the Immune System

Weiskopf Lab

The Weiskopf is devoted to understanding T cell responses in emerging infectious viruses relevant to human health and disease.

Vijayanand Lab

Pandurangan Vijayanand, M.D., Ph.D., and his lab members employ genomics tools to understand, diagnose and treat pulmonary disease such as asthma, lung cancer and infectious diseases, including the novel coronavirus.

Shresta Lab

Sujan Shresta, Ph.D., and her team study the immunology and virology of mosquito-borne human pathogens such as dengue virus and Zika virus.

Sharma Lab

Sonia Sharma, Ph.D., and her lab members lead unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells.

Schmiedel Lab

Dr. Schmiedel is dedicated to shedding light on the genetic mechanisms driving the pathogenesis of human diseases. His research is revealing molecular features regulating immune cell function to enhance our understanding and advance disease diagnosis, treatment, and prevention.

Saphire Lab

Erica Ollmann Saphire, Ph.D., MBA, studies, at the molecular level, how and why viruses are pathogenic. This work provides the roadmap for medical defense.

Rao Lab

Anjana Rao, Ph.D., focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

Myers Lab

Samuel Myers, Ph.D., studies the signaling circuits that drive the behavior of individual immune cells and ultimately orchestrate systemic immune responses.

Crotty Lab

Shane Crotty, Ph.D., and his team study immunity against infectious diseases. They investigate how the immune system remembers infections and vaccines.

Zika

Microscopy image showing immune cell responses to Zika virus.
LJI scientists are investigating new strategies for stopping Zika virus.

Type 1 Diabetes

Type 1 diabetes accounts for up to 2 million U.S. cases and occurs when the immune system mistakenly destroys insulin-producing cells in the pancreas.

Lassa Fever

Lassa virus is endemic to West Africa and kills nearly 5,000 people a year. Research led by La Jolla Institute scientists lays the groundwork for anti-Lassa vaccine development.

COVID-19

Scientists in the La Jolla Institute for Immunology (LJI) remain at the forefront of research into COVID-19 vaccines, therapies, and the disease's long-term effects.

CMV

CMV is the number one infectious cause of congenital birth defects worldwide. Researchers at La Jolla Institute are working to define the molecular underpinnings of CMV infection.

Atopic Dermatitis / Eczema

Atopic dermatitis occurs when a person’s immune system causes inflammation of the skin, which also makes the skin more vulnerable to environmental irritants and allergens.

Heart Disease

Heart disease, also called cardiovascular disease, can describe several conditions, including coronary artery disease and aortic athlerosclerosis.

Asthma

Asthma affects more than 25 million people across the nation—7 million of them children—and the incidence is rising.

Alzheimer’s disease

La Jolla Institute scientists are working to understand how the body's T cells may target the proteins involved in the plaques and tangles seen in brains with Alzheimer's disease.

Reina Lab

Dr. Reina-Campos’ lab seeks to understand the underlying principles governing tissue immune networks that enable robust and long-term protection against infection and tumors.

Ay Lab

Ferhat Ay, Ph.D., works to understand gene regulation in complex organisms and diseases.