Daniela Weiskopf, Ph.D.
Assistant Professor
Center for Sex-based Differences in the Immune System, Center for Vaccine Innovation
“I was always amazed how an infection with one virus can have such different outcomes in people: infection with one virus can be without symptoms, result in disease, or even death.”

Overview

My lab is devoted to understanding T cell responses in emerging infectious viruses relevant to human health and disease. In 2009, I received my Ph.D. in Immunology from Innsbruck Medical University, Austria, where I performed research analyzing post-translational modifications of viral-derived epitopes and modulation of the T cell immune response during aging. Following my Ph.D., I obtained post-doctoral training under Dr. Alessandro Sette at La Jolla Institute for Immunology (LJI). In 2020 I joined the Center for Infectious Disease and Vaccine Research at LJI as a Research Assistant Professor.
My lab characterizes human immune responses to dengue virus, zika virus, and chikungunya virus. With the emergence and pandemic spread of the novel coronavirus (SARS-CoV-2) in 2020, we focused on deciphering the human T cell response against SARS-CoV-2 after natural infection and vaccination.

As of 2023, the focus of my lab has reverted back to discovering how the human immune system reacts to emerging infectious viruses. The virus family I focus on is termed Arboviruses and includes virus families such as Flaviviruses (dengue virus) and Alphaviruses (chikungunya virus).

One thing that is shared between all of these viral infections is the wide range of symptoms that are elicited upon infection in human populations. The range of infections with either of these viruses can range from asymptomatic to severe and/or chronic disease.

This broad response reflects the complex interactions between these viruses, and the host immune system. Understanding the factors influencing the variability in symptoms is essential to inform vaccine design and to developed effective strategies, diagnosis, and treatment of arbovirus diseases.

Featured publications

Aug 4, 2020 Science
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D.
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Lab Members

RA
SC
CH
AN
JV
DW

From the lab

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Awards & Honors

  • 2018 The Tullie and Ricky Families SPARK Awards for Innovations in Immunology
  • 2021 ASciNA Award, Junior Principal Investigator
  • 2022 Elsevier Early Career Scientist Award, Elsevier
  • 2022 Highly Cited Researcher by Clarivate™
  • 2023 Highly Cited Researcher by Clarivate™
  • 2023 Portrayed by Nature as one of four researchers on the fast track to impact